Rifampicin, Isoniazid and Ppyrazinamide are all antitubercular drugs which possess an active bactericidal action. Rifampicin inhibits DNA-dependent RNA polymerase activity in susceptible cells and has broad spectrum activity against most gram-positive and gram-negative bacteria, especially Mycobacterium tuberculosis. Isoniazid inhibits the synthesis of mycolic acids, which is an essential component of the bacterial cell wall. Pyrazinamide, a highly specific agent, is active only against Mycobacterium tuberculosis, and active only at a slightly acid pH. Combination of these agents covers activity against the 3 different bacterial populations.
Use this medication precisely as recommended by your physician. Follow the prescription of your doctor carefully.
The medication dose given by your physician is based on your health conditions, other medications or food supplements taken, and your reaction to the treatment. To diminish risks for adverse effects, do not increase your dosage, thus take it regularly, or take it as instructed by your physician. Adverse events may still happen even at usual prescription dosages.
If your physician requests you to use this drug consistently, take it regularly to get the most benefits from it. To make you remember it better, take it at a fixed time every day.
Your doctor may need to modify your dosages to ease your symptoms or if you develop adverse reactions.
If you have any inquiries with regards to information, ask your physician or pharmacist.
