If you have recurrent multiple myeloma, there’s a decent possibility it will return after effective treatment. At the point when this occurs, it’s called recurrent or relapsed. If it doesn’t react to treatment or returns within 60 days after your last treatment, it’s known as refractory.


You’ll presumably have a great deal of inquiries and concerns. Know that treatment alternatives are accessible, regardless of whether your cancer returns.


And keeping in mind that you can’t stay away from a relapse, you might have the option to detect certain signs and indications prior, which could prompt better care.

Treatment slaughters the vast majority of the myeloma cells in your body, however, some can endure and survive. These cells may, in the end, develop and isolate, which prompts a relapse.


  • Indolent or low risk: Your primary care physician may attempt a treatment you’ve just had.
  • Aggressive or high risk: Your primary care physician may recommend another treatment.


If your disease returns, similar problems you had when you were first diagnosed may manifest once more. Or on the other hand, you may have new problems. Some common symptoms are:

  • Bone pain
  • Bone breaks
  • Fever
  • Fatigue
  • Weight loss
  • Easy bruising
  • Trouble breathing
  • Weakness in the arms or legs


Your primary care physician will request for tests to check the status of your myeloma while you’re in remission. These may include:

  • Blood or urine test
  • Bone marrow biopsy
  • Bone scan
  • Computed tomography (CT) scan
  • Magnetic resonance imaging (MRI)
  • Physical exam

Strange outcomes could imply that the condition has returned.


There are many treatment options if you have a relapse. The most widely recognized include:

Chemotherapy. This treatment destroys cancer cells in your body. If your multiple myeloma returns, you may get a higher portion of an alternate course of medications, for example,

  • Cyclophosphamide (Cytoxan, Neosar)
  • Doxorubicin (Adriamycin, Rubex)
  • Melphalan (Alkeran)
  • Vincristine (Oncovin, Vincasar, Vincrex)

Your PCP may likewise attempt high-portion steroids alone.

Stem cell transplant. The high portions of chemo or radiation used to treat a numerous myeloma relapse can execute the stem cells in your bone marrow. To secure them and keep them safe, your primary care physician obtains undifferentiated cells, usually from your hip. They’ll utilize a major needle to haul out the fluid marrow while you’re snoozing. The cells are solidified and came back to your body through a vein after your treatment.

Targeted therapies. These drugs target explicit pieces of cells that help cancer cells develop, partition, or spread. Those utilized for recurrent multiple myeloma include:

  • Thalidomide (Thalomid)
  • Selinexor (Xpovio)
  • Pomalidomide (Pomalyst)
  • Panobinostat (Farydak)
  • Lenalidomide (Revlimid)
  • Ixazomib (Ninlaro)
  • Elotuzumab (Empliciti)
  • Daratumumab (Darzalex)
  • Carfilzomib (Kyprolis)
  • Bortezomib (Velcade)

You could likewise get a mix of these medications.

Clinical trials. You should consider this if your disease returns. These treatment options allow you to attempt new medicines that aren’t generally accessible.

Palliative care. Your primary care physician may likewise offer this to facilitate your indications or oversee complexities.

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