Watsons Health

RECOMBINANT HUMAN ERYTHROPOIETIN ALFA

Erythropoietin (EPO) is a glycoprotein hormone created by the kidney when there is hypoxia and is the key controller of red blood cell production. EPO is associated with all periods of erythroid growth, and has its main impact at the stage of erythroid precursors. After EPO binds to its cell surface receptors, it actuates signal transduction pathways that meddle with apoptosis and activates erythroid cell proliferation.

Erythropoietin is a growth factor hormone that basically stimulates the production of red cells. Erythropoietin receptors are found on the surface of many tumor cells.

Recombinant Human Erythropoietin Alfa is used in the following:

  • Symptomatic anaemia associated withchronic renal failure
  • Anemia on adult patient on haemodialysis, peritoneal dialysis, withrenal insufficiency not yet undergoing dialysis
  • Anemia and receiving chemotherapy for solid tumours, malignant lymphoma or multiple myeloma, andat risk of transfusion

Do not give Recombinant Human Erythropoietin Alfa to people with the following conditions:

  • Hypersensitivity
  • Pure red cell aplasia (PRCA) following treatment withany erythropoietin.
  • Uncontrolled hypertension
  • Severe heart, peripheral arterial, carotid orcerebral vascular disease
  • Recent myocardial infarction or cerebrovascular accident
  • Surgery patients who can not receive adequate antithrombotic prophylaxis

Recombinant Human Erythropoietin Alfa may have the following side effects:

  • Dose-dependent increase in blood pressureor aggravation of existing hypertension
  • Diarrhea
  • Nausea
  • Vomiting
  • Fever
  • Headache
  • Venous andarterial thromboses
  • Hypertension
  • Cough
  • Rash
  • Arthralgia
  • Bone pain
  • Myalgia
  • Pain in extremities
  • Chills
  • Influenza-like illness
  • Injection site reaction
  • Peripheral edema

Precautions

Take extra caution in patients with the following medical conditions:

  • Hypertension
  • Epilepsy
  • History of seizures
  • Central nervous system infection andbrain metastases
  • Chronic liver failure
  • Porphyria
  • Stroke
  • Pregnancy & lactation

 

Interactions

Recombinant Human Erythropoietin Alfa may interact with the following medicines:

  • Drugs that decrease erythropoiesis
  • Cyclosporin

Overdose can lead to excessively high hemoglobin levels. Seek medical help immediately.

Available Brands:

Dypotin, Efotin, Epogen, Epokine, Eposino, Eposis, Epotin, Epovax, Eprex,

Eprex, Renogen, Zyrop

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