RAMOSETRON

Ramosetron is a 5-HT3 receptor antagonist. It exerts its antiemetic property by blocking of serotonin to 5-HT3 receptors present in the afferent vagal nerve-endings in the GI mucosa.

Ramosetron is used in the treatment of nausea and vomiting associated with cancer chemotherapy.

Ramosetron is not recommended in lactation and in children. A patient with diabetes or hypertension needs to be warned about a few drug interactions. Certain medications should be avoided in pregnant or breastfeeding women. A few drugs should be avoided by patients with hepatitis or cardiac diseases.

Ramosetron may bring about some side effects such as the following:

  • Headache
  • Diarrhoea
  • Constipation
  • Rash
  • Itching
  • Redness
  • Heat
  • Hot flushes
  • Hiccups
  • Numbness of tongue
  • Hepatic dysfunction (increased AST, ALT, GPT, and bilirubin)
  • Increased BUN
  • Epileptiform attacks have been reported with other 5-HT3 antagonists.
  • Potentially fatal symptoms are shock or anaphylactoid symptoms.

Precautions:

Take precautions in elderly and in pregnant women. This drug is not recommended in lactation. Safety and efficacy in paediatric population has not been established.

 

Interactions:

Ramosetron may increase plasma concentration when given with fluvoxamine (CYP1A2 inhibitor).

Interactions may differ from drug to drug, and most medications may interact with alcohol and tobacco, so be careful.

If you think you may have used Ramosetron more than the usual recommended dosage, seek medical help immediately.

 

Available Brands:

Ai Ke An, Irribow, Irribow OD, Lei Mai Xin, Nasea, Nasea OD, and Ramea.

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