RALTITREXED

Raltitrexed is a drug that belongs to a class of medicines known as antimetabolites. It is used to treat colorectal cancer and is a folate analogue. It inhibits DNA synthesis and leads to cell death by being a thymidylate synthase (TS) potent inhibitor.

Raltitrexed is for the palliative treatment of advanced colorectal cancer.

Raltitrexed should not be given to people who have severe kidney disease, women who are pregnant and women who are breastfeeding.

Raltitrexed may give rise to the following side effects:

  • Headache
  • Nausea
  • Vomiting
  • Diarrhoea
  • Abdominal pain
  • Constipation
  • Dehydration
  • Dyspepsia
  • Fever
  • Rash
  • Pruritus
  • Pain
  • Taste perversion
  • Anorexia
  • Weight loss
  • Asthenia
  • Malaise
  • Arthralgia
  • Infections
  • Alopecia
  • Mucositis
  • Stomatitis
  • Conjunctivitis
  • Cellulitis
  • Sepsis
  • Peripheral oedema
  • Anaemia
  • Leucopenia
  • Thrombocytopenia
  • Hypertonia
  • Hyperbilirubinaemia
  • Increased AST and ALT
  • Increased alkaline phosphatase
  • Increased serum creatinine

Precautions

Take caution in those with the following conditions:

  • Depressed bone morrow function
  • Poor general condition
  • History of gastrointestinal diseases
  • Prior radiotherapy
  • Elderly
  • Kidney problems
  • Liver problems

 

Interactions

Raltitrexed may interact with the following medicines:

  • Folic acid
  • Folinic acid
  • Methylfolate

Symptoms of overdose include haematological and gastrointestinal toxicity.

Seek medical help immediately.

 

Available Brand:

  • Tomudex

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