Quinapril and hydrochlorothiazide both decrease blood pressure via different but complementary mechanisms. Quinapril, a prodrug of quinaprilat, is an ACE inhibitor which prevents conversion of angiotensin I to angiotensin II thereby increasing plasma renin activity and reducing aldosterone secretion. The thiazide diuretic hydrochlorothiazide prevents sodium reabsorption in the distal tubules, leading to increased excretion of Na, K, Cl, Mg, water and hydrogen ions.
Use this medication precisely as recommended by your physician. Follow the prescription of your doctor carefully.
The medication dose given by your physician is based on your health conditions, other medications or food supplements taken, and your reaction to the treatment. To diminish risks for adverse effects, do not increase your dosage, thus take it regularly, or take it as instructed by your physician. Adverse events may still happen even at usual prescription dosages.
If your physician requests you to use this drug consistently, take it regularly to get the most benefits from it. To make you remember it better, take it at a fixed time every day.
Your doctor may need to modify your dosages to ease your symptoms or if you develop adverse reactions.