QUINAPRIL + HYDROCHLOROTHIAZIDE - Uses, Warnings, Side effects
HUMAN PAPILLOMAVIRUS 9-VALENT VACCINE

QUINAPRIL + HYDROCHLOROTHIAZIDE

Quinapril and hydrochlorothiazide both decrease blood pressure via different but complementary mechanisms. Quinapril, a prodrug of quinaprilat, is an ACE inhibitor which prevents conversion of angiotensin I to angiotensin II thereby increasing plasma renin activity and reducing aldosterone secretion. The thiazide diuretic hydrochlorothiazide prevents sodium reabsorption in the distal tubules, leading to increased excretion of Na, K, Cl, Mg, water and hydrogen ions.

Use this medication precisely as recommended by your physician. Follow the prescription of your doctor carefully.

The medication dose given by your physician is based on your health conditions, other medications or food supplements taken, and your reaction to the treatment. To diminish risks for adverse effects, do not increase your dosage, thus take it regularly, or take it as instructed by your physician. Adverse events may still happen even at usual prescription dosages.

If your physician requests you to use this drug consistently, take it regularly to get the most benefits from it. To make you remember it better, take it at a fixed time every day.

Your doctor may need to modify your dosages to ease your symptoms or if you develop adverse reactions.

Quinapril + Hydrochlorothiazide is used in the following conditions:

  • Hypertension

This medicine may be recommended for different uses. Approach your physician or pharmacist for more information.  

Do not use Quinapril + Hydrochlorothiazide in people with the following conditions:

  • Hypersensitivity
  • History of angioedema related to previous ACE inhibitor treatment
  • Hereditary or idiopathic angioneurotic edema
  • Dynamic left ventricular outflow obstruction
  • Anuria
  • Severe renal impairment
  • Pregnancy (2nd-3rd trimester)
  • Concomitant use with aliskiren in patients with diabetes mellitus or renal impairment (GFR <60 mL/min/1.73 m2)
  • Concomitant use with sacubitril/valsartan

Quinapril + Hydrochlorothiazide may have the following side effects:

  • Symptomatic hypotension with or without syncope
  • Intestinal angioedema
  • Electrolyte disturbances 
  • Cough
  • Gout
  • Hematologic effects 
  • Ocular effects 
  • Sensitivity reactions 
  • Non-melanoma skin cancer
  • Stevens-Johnson syndrome
  • SLE exacerbation or activation
  • Elevated BUN
  • Increased serum creatinine
  • Oliguria
  • Progressive azotaemia
  • Angina pectoris
  • Tachycardia
  • Palpitation
  • Tinnitus
  • Amblyopia
  • Blurred vision
  • Nausea
  • Vomiting
  • Diarrhea
  • Abdominal pain
  • Dry mouth
  • Fatigue
  • Asthenia
  • Pyrexia
  • Edema
  • Hepatitis
  • Urticaria
  • Elevated hepatic enzymes
  • Hyperuricemia
  • Impaired glucose tolerance
  • Back pain
  • Myalgia
  • Headache
  • Dizziness
  • Somnolence
  • Vertigo
  • Insomnia
  • Confusion
  • Depression
  • Dyspnea
  • Bronchitis
  • Sinusitis
  • Rash
  • Pruritus
  • Alopecia
  • Hyperhidrosis
  • Vasodilation
  • Orthostatic hypotension

Potentially Fatal: 

  • Laryngeal angioedema
  • Arrhythmia
  • Cholestatic jaundice progressing to fulminant hepatic necrosis
  • Acute renal failure
  • Anaphylactoid reactions

Keep in mind that your physician has recommended this drug since he or she has known that the advantage to you is more significant than the risk of adverse reactions. Many individuals utilizing this medicine don’t have serious side effects.  

A severe allergy to this medication is uncommon. In any case, seek emergency medical help if you see any manifestations of a serious allergic response, including a rash, tingling or swelling particularly of the face or tongue or throat, dizziness or difficulty in breathing.

This is not a complete list of side effects. If you see other effects not recorded above, contact your physician or pharmacist.

Precautions

Take extra caution in patients with the following medical conditions:

  • Adrenal insufficiency
  • Aortic stenosis
  • Ischemic heart disease
  • Cerebrovascular disease
  • Collagen vascular disease
  • SLE
  • Prediabetes or diabetes mellitus
  • Salt or volume depletion
  • Hypercholesterolemia
  • Hypercalcemia
  • Liver cirrhosis
  • Hypertrophic cardiomyopathy with outflow obstruction
  • Unstented unilateral/bilateral renal artery stenosis
  • Parathyroid disease
  • History of allergy 
  • Bronchial asthma
  • Undergoing major surgery or during anesthesia
  • Black race
  • Undergoing LDL apheresis with dextran sulfate cellulose or desensitisation treatment with hymenoptera venom
  • Renal and hepatic impairment
  • Pregnancy (1st trimester)
  • Lactation

Prior in taking this medicine, tell your physician or pharmacist if you have allergies  or other hypersensitivity reactions with the drug. This drug may contain inert ingredients which can cause unfavorable side effects or different issues. Talk with your pharmacist for more information.

Interactions

Quinapril + Hydrochlorothiazide may interact with the following medicines:

  • Nitrates
  • Vasodilators
  • Diuretics
  • Barbiturates
  • Narcotics 
  • Antacids

Quinapril: 

  • Heparin
  • Sulfamethoxazole/trimethoprim
  • K-sparing diuretics
  • K supplements
  • K-containing salts. 
  • Tetracyclines. 
  • Rapamycin 
  • Temsirolimus
  • Sirolimus
  • Racecadotril
  • Vildagliptin
  • NSAIDs, including selective COX-2 inhibitors. 
  • Allopurinol
  • Procainamide
  • Cytostatic and immunosuppressive agents
  • Insulin
  • Oral hypoglycemic agents

Hydrochlorothiazide:

  • Lithium 
  • Norepinephrine
  • Tubocurarine
  • NSAIDs 
  • Digitalis glycosides
  • Corticosteroids
  • ACTH
  • Colestipol
  • Cholestyramine

Potentially Fatal: 

Quinapril: 

  • Aliskiren
  • Sacubitril
  • Valsartan

Inform your physician about the drugs you take including over-the-counter medications, prescribed drugs, supplements and vitamins.

This is not a complete list of drug interactions. Approach your physician or pharmacist for more details.

The effects of certain medications can change if you consume different medications or herbal products simultaneously. This can build your risk for side effects or may cause your drugs not to work effectively. These interactions are possible, yet don’t generally happen. Your physician or pharmacist can prevent or oversee interactions by changing how you utilize your prescriptions or by close checking.

While utilizing this drug, don’t start, stop, or change the dose of other medicines you are using without your physician’s advice.

If an overdose is suspected, call your health care provider immediately.

Available brands:

  • Accuretic

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