Quadrivalent Human Papillomavirus Types 6, 11, 16, 18 recombinant vaccine is a vaccine for human papilloma virus infection prevention. It is manufactured from the sterile virus-like particles (VLPs) of the major capsid (L1) protein of HPV Types 6, 11, 16, and 18. The L1 proteins are created by separate fermentations in recombinant Saccharomyces cerevisiae and is self-assembled into VLPs.
L1 capsids are produced by individually fermenting in recombinant Saccharomyces cerevisiae and assembled into VLPs. Since these particles do not contain viral DNA, they are unable to infect human cells or multiply.