PIPERACILLIN

COMMON BRAND NAME(S): Pipracil

GENERIC NAME(S): PIPERACILLIN SODIUM

Description: Piperacillin is an antibacterial that inhibits the cell wall synthesis and kill the bacteria.
Pharmacokinetics:
Absorption: Well absorbed after IM inj. Time to peak plasma concentration: 30-50 min.
Distribution: Widely distributed in body tissues and fluids. Crosses the placenta into the foetal circulation and enters breast milk (small amounts). Plasma protein binding: Approx 20%.
Excretion: Via urine (approx 60-80%) as unchanged drug and bile (up to 20%). Plasma half-life: Approx 1 hr.

Uses

This medication is used to treat a wide variety of bacterial infections. It is also used before certain surgeries to prevent bacterial infections. This medication is known as a penicillin-type antibiotic. It works by stopping the growth of bacteria.

How to use piperacillin intravenous:

This medication is given by injection into a vein as directed by your doctor. The dosage is based on your medical condition, weight, and response to therapy.

If you are giving this medication to yourself at home, learn all preparation and usage instructions from your health care professional. Before using, check this product visually for particles or discoloration. If either is present, do not use the liquid. Learn how to store and discard medical supplies safely.

Give aminoglycosides (such as gentamicin) separately from this medication. Do not mix together in the same IV fluid.

Antibiotics work best when the amount of medicine in your body is kept at a constant level. Therefore, use this drug at evenly spaced intervals.

Continue to use this medication until the full prescribed amount is finished, even if symptoms disappear after a few days. Stopping the medication too early may allow bacteria to continue to grow, which may result in a return of the infection.

Tell your doctor if your condition persists or worsens.

Warnings

Pregnancy Risk: Category B (No proven risk in humans)

Side Effects

Diarrhea, nausea, vomiting, headache, or dizziness may occur. If these effects persist or worsen, notify your doctor or pharmacist promptly.

Tell your doctor right away if you have any serious side effects, including: pain/swelling at injection site or arms/legs, extreme tiredness, easy bruising/bleeding, new signs of infection (e.g., fever, persistent sore throat), dark/cloudy urine, change in the amount of urine, severe abdominal/stomach pain, yellowing eyes/skin, persistent nausea/vomiting, seizures, uncontrolled movements, confusion, muscle cramps, irregular heartbeat.

This medication may rarely cause a severe intestinal condition (Clostridium difficile-associated diarrhea) due to a type of resistant bacteria. This condition may occur during treatment or weeks to months after treatment has stopped. Do not use anti-diarrhea products or narcotic pain medications if you have any of the following symptoms because these products may make them worse. Tell your doctor immediately if you develop: persistent diarrhea, abdominal or stomach pain/cramping, blood/mucus in your stool.

Use of this medication for prolonged or repeated periods may result in oral thrush or a new vaginal yeast infection. Contact your doctor if you notice white patches in your mouth, a change in vaginal discharge, or other new symptoms.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Precautions

Precautions

Before using this medication, tell your doctor or pharmacist if you are allergic to it; or to penicillin or cephalosporin antibiotics; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, liver disease.

This medication contains sodium. Consult your doctor or pharmacist if you are on a salt-restricted diet or if you have a condition that could be worsened by an increase in salt intake (e.g., congestive heart failure).

Before having surgery, tell your doctor or dentist that you are using this medication.

Kidney function declines as you grow older. This medication is removed by the kidneys. Therefore, elderly people may be at greater risk for side effects while using this drug.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

This drug passes into breast milk. Consult your doctor before breast-feeding.

Interactions

Some products that may interact with this drug include: “blood thinners” (e.g., warfarin), live bacterial vaccines, methotrexate, tetracyclines.

Although most antibiotics probably do not affect hormonal birth control such as pills, patch, or ring, some antibiotics may decrease their effectiveness. This could cause pregnancy. Examples include rifamycins such as rifampin or rifabutin. Be sure to ask your doctor or pharmacist if you should use additional reliable birth control methods while using this antibiotic.

This medication may interfere with certain laboratory tests (including certain urine glucose tests), possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug.

Overdose & Brands

Overdose

If overdose is suspected, contact a poison control center or emergency room immediately. Symptoms of overdose may include: seizures, confusion, mental/mood changes (e.g., agitation).

Notes

Laboratory and/or medical tests (e.g., kidney/liver function, complete blood count) may be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details.

Missed Dose

For the best possible benefit, it is important to receive each scheduled dose of this medication as directed. If you miss a dose, contact your doctor or pharmacist immediately to establish a new dosing schedule. Do not double the dose to catch up.

Storage

Consult the product instructions and your pharmacist for storage details. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Brands

There are no brands containing this molecule.