Perindopril, a prodrug of perindoprilat, is an angiotensin-converting enzyme (ACE) inhibitor. It increases the function of plasma renin while decreasing the production of aldosterone and vasoconstriction.

Use this medication precisely as recommended by your physician. Follow the prescription of your doctor carefully.

The medication dose your physician has given is based on your condition, other medications or food supplements you may take, and your reaction to treatment. To diminish your risks for adverse effects, don’t increase your dosage, take it regularly, or take it as instructed by your physician. Adverse events may still happen even at usual prescription dosages.

If your physician requests you to use this drug consistently, use it regularly to get the most benefits from it. To make you remember it better, take it at a fixed time every day.

Your doctor may need to modify your dosages to ease your symptoms or if you develop adverse reactions.

If you have any inquiries with regards to information, ask your physician or pharmacist.

Perindopril is used in the following conditions:

  • Stable coronary artery disease
  • Heart failure
  • Hypertension

This medicine may be recommended for different uses. Approach your physician or pharmacist for more information.  

Do not use Perindopril in people with the following conditions:

  • Lactation
  • Pregnancy
  • Using valsartan/sacubitril
  • Patients taking aliskiren, particularly those with renal impairment or diabetes (GFR 60 mL/min/1.73 m2).
  • Patients undergoing extracorporeal therapies, this results in the blood contracting with negatively charged surfaces
  • Unilateral or bilateral renal stenosis
  • Idiopathic or hereditary angioedema
  • Angioedema associated with past ACE inhibitor therapy

Perindopril may have the following side effects:

  • Raynaud’s phenomenon
  • Epistaxis
  • Impaired peripheral circulation
  • Flushing
  • Vasculitis
  • Rash
  • Pruritis
  • Bronchospasm
  • Dyspnea
  • Erectile dysfunction
  • Proteinuria
  • Renal deficiency
  • Sleep disorders
  • Mood disturbances
  • Dizziness
  • Dysgeusia
  • Vertigo
  • Paresthesia
  • Headache
  • Muscle cramps
  • Increased serum bilirubin
  • Increased serum creatinine
  • Elevated BUN
  • Urticaria
  • Peripheral edema
  • Asthenia
  • Abdominal pain
  • Vomiting
  • Dyspepsia
  • Diarrhea
  • Constipation
  • Nausea
  • Visual disturbance
  • Tinnitus
  • Tachycardia
  • Palpitation
  • Thrombocytopenia
  • Anemia
  • Agranulocytosis
  • Neutropenia
  • Cough
  • Hyperkalaemia
  • Syncope
  • Hypotension
  • Cholestatic jaundice
  •  Hypotension

Potentially Fatal:

  • Fulminant hepatic necrosis
  • Arrhythmia
  • Angioedema

Keep in mind that your physician has recommended this drug since he or she has known that the advantage to you is more noteworthy than the risk of adverse reactions. Many individuals utilizing this medicine don’t have serious side effects. 

A serious allergy to this medication is uncommon. In any case, seek emergency medical help if you see any manifestations of a serious allergic response, including a rash, tingling or swelling particularly of the face or tongue or throat, dizziness or difficulty in breathing.

This is not a complete list of side effects. If you see other effects not recorded above, contact your physician or pharmacist.


Take extra caution in patients with the following medical conditions:

  • Elderly
  • Hepatic and renal dysfunction
  • Desensitization therapy (e.g. Hymenoptera venom)
  • Black race
  • Patients who are sedated or undergoing major surgery
  • Ischaemic heart disease
  • Primary aldosteronism
  • Diabetes
  • Refractory ascites
  • Ascites due to cirrhosis
  • Aortic and severe mitral valve stenosis
  • Vascular Collagen Disease
  • Depletion of volume or salt
  • Outflow tract blockage in a patient with hypertrophic cardiomyopathy

Prior to taking this medicine, tell your physician or pharmacist if you are allergic to it, or if you have some other hypersensitivities. This drug may contain inert ingredients, which can cause unfavorable side effects or different issues. Talk with your pharmacist for more information.


Perindopril may interact with the following medicines:

  • Na aurothiomalate
  • NSAIDs
  • Linagliptin
  • Sitagliptin
  • Racecadotril
  • Everolimus
  • Sirolimus
  • Temsirolimus
  • Oral hypoglycemics agents
  • Insulin
  • Heparin
  • Ciclosporin
  • Trimethoprim
  • K supplements
  • Eplerenone
  • Spironolactone
  • Baclofen
  • Diuretics
  • Antihypertensive agents

Potentially Fatal:

  • Valsartan/sacubitril
  • Aliskiren

Inform your physician about the drugs you take including over-the-counter medications, prescribed drugs, supplements and vitamins.

This is not a complete list of drug interactions. Approach your physician or pharmacist for more details.

The effects of certain medications can change if you consume different medications or herbal products simultaneously. This can build your risk for side effects or may cause your drugs not to work effectively. These interactions are conceivable, yet don’t generally happen. Your physician or pharmacist can prevent or oversee interactions by changing how you utilize your prescriptions or by close checking.

While utilizing this drug, don’t start, stop, or change the dose of other medicines you are using without your physician’s advice. 

Symptoms of overdose may include the following: 

  • Cough
  • Anxiety
  • Dizziness
  • Palpitations
  • Tachycardia
  • Electrolyte disturbances
  • Hyperventilation
  • Renal failure
  • Circulatory shock
  • Bradycardia
  • Hypotension

Seek medical help immediately.

Available Brands:

  • Peripil 4
  • Perigard-2/Perigard-4
  • Hypergo
  • Coversyl

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