PERINDOPRIL + INDAPAMIDE

Perindopril + Indapamide lower blood pressure via independent but complementary processes, resulting in additive benefits when used together.

Perindopril, a prodrug of perindoprilat, is an angiotensin-converting enzyme (ACE) inhibitor. It increases the function of plasma renin while decreasing the production of aldosterone and vasoconstriction.

Indapamide is a diuretic that works similarly to thiazides. It increases sodium, chloride, and water outflow by disrupting the Na ion transport through the renal tubular epithelium.

Use this medication precisely as recommended by your physician. Follow the prescription of your doctor carefully.

The medication dose your physician has given is based on your condition, other medications or food supplements you may take, and your reaction to treatment. To diminish your risks for adverse effects, don’t increase your dosage, take it regularly, or take it as instructed by your physician. Adverse events may still happen even at usual prescription dosages.

If your physician requests you to use this drug consistently, use it regularly to get the most benefits from it. To make you remember it better, take it at a fixed time every day.

Your doctor may need to modify your dosages to ease your symptoms or if you develop adverse reactions.

If you have any inquiries with regards to information, ask your physician or pharmacist. 

Perindopril + Indapamide is used in the following conditions:  

  • Essential hypertension

This medicine may be recommended for different uses. Approach your physician or pharmacist for more information.  

Do not use Perindopril + Indapamide in people with the following conditions:

  • Concomitant use with aliskiren in people with mild to extreme renal impairment or diabetes mellitus (GFR 60 mL/min/1.73 m2)
  • Lactation
  • Pregnancy
  • Mild to extreme renal insufficiency and serious liver failure (based on fixed-dose combination).
  • People receiving extracorporeal therapies, which cause blood to come into contact with negatively charged surfaces.
  • Hepatic encephalopathy
  • Hypokalaemia
  • Bilateral or unilateral renal artery stenosis
  • Idiopathic or hereditary angioedema
  • Angioedema caused by prior ACE inhibitor therapy
  • Indapamide or sulfonamide-related drugs
  • Extreme sensitivity to perindopril

Perindopril + Indapamide may have the following side effects:

  • Pruritus
  • Maculopapular rash
  • Dyspnea
  • Paraesthesia
  • Headache
  • Dizziness
  • Muscle cramps
  • Anorexia
  • Asthenia
  • Dry mouth
  • Dyspepsia
  • Constipation
  • Abdominal pain
  • Diarrhea
  • Vomiting
  • Nausea
  • Visual Impairment
  • Tinnitus
  • Vertigo
  • Thrombocytopenia
  • Anemia
  • Agranulocytosis
  • Neutropenia with myeloid hypoplasia
  • Hyperuricaemia
  • Proteinuria
  • Progressive azotaemia
  • Acute renal failure
  • Oliguria
  • High-level serum creatinine and BUN
  • Hepatic encephalopathy
  • High-level serum bilirubin and liver enzymes
  • Hypercalcaemia
  • Hypophosphataemia
  • Hyponatraemia
  • Hypochloraemia
  • Hypokalaemia
  • Hyperkalaemia
  • Stevens-Johnson syndrome
  • Rosacea
  • Pemphigus like rash
  • Psoriasis
  • Lichenoid eruptions
  • Maculopapular pruritic rashes
  • SLE activation or exacerbation
  • Dysgeusia
  • CNS depression
  • Acute angle-closure glaucoma
  • Acute transient myopia
  • Photosensitivity
  • Syncope
  • Hypotension
  • Cough

Potentially Fatal: 

  • Responses to anaphylactoid/anaphylactic substances
  • Cholestatic jaundice that has the possibility of progressing to fulminant hepatic necrosis
  • Arrhythmias
  • Angioedema accompanied by laryngeal edema

Keep in mind that your physician has recommended this drug since he or she has known that the advantage to you is more noteworthy than the risk of adverse reactions. Many individuals utilizing this medicine don’t have serious side effects. 

A serious allergy to this medication is uncommon. In any case, seek emergency medical help if you see any manifestations of a serious allergic response, including a rash, tingling, or swelling particularly of the face or tongue or throat, dizziness, or difficulty in breathing.

This is not a complete list of side effects. If you see other effects not recorded above, contact your physician or pharmacist.

Take extra caution in patients with the following medical conditions:

  • Elderly
  • Hepatic and renal impairment 
  • Black race
  • People suffering from primary aldosteronism
  • Person having a major operation, Hymenoptera venom desensitization therapy, and LDL apheresis with dextran sulfate
  • Penicillin allergy
  • Health records of gout
  • Cirrhosis
  • Collagen vascular disease (e.g. SLE)
  • Metabolic acidosis
  • Volume insufficiency
  • Dehydrated state
  • Diabetes mellitus or prediabetes
  • Mitral valve or aortic stenosis
  • Hypertrophic cardiomyopathy with blockage of the outflow tract
  • Acute cardiac decompensation
  • Cerebrovascular disease
  • Long QT syndrome
  • Cardiac failure
  • Ischaemic heart disease

Prior to taking this medicine, tell your physician or pharmacist if you are allergic to it, or if you have some other hypersensitivities. This drug may contain inert ingredients, which can cause unfavorable side effects or different issues. Talk with your pharmacist for more information.

Interactions

Perindopril + Indapamide may interact with the following medicines:

  • Digitalis
  • Terfenadine
  • Astemizole
  • Methadone
  • Vincamine
  • Pentamidine
  • Moxifloxacin
  • Mizolastine
  • Halofantrine
  • Erythromycin
  • Cisapride
  • Bepridil
  • Tiapride
  • Sultopride
  • Amisulpride
  • Pimozide
  • Trifluoperazine
  • Thioridazine
  • Chlorpromazine
  • Dofetilide
  • Amiodarone
  • Disopyramide
  • Quinidine
  • Stimulant laxatives
  • Systemic mineralocorticoids
  • Glucocorticoids
  • IV amphotericin B
  • Na aurothiomalate
  • Procainamide
  • Corticosteroids
  • Immunosuppressants
  • Allopurinol
  • Vildagliptin
  • Linagliptin
  • Temsirolimus
  • Everolimus
  • Sirolimus
  • Rapamycin
  • Racecadotril
  • Oral hypoglycemic agents
  • Insulin
  • Salt replacements containing K
  • K supplements
  • K-sparing diuretics
  • Co-trimoxazole
  • Anesthetics
  • Estramustine
  • Angiotensin-receptor blockers
  • Sympathomimetic drugs
  • NSAIDs
  • TCAs
  • Baclofen
  • Vasodilators
  • Antihypersensitive agents

Potentially Fatal:

  • Dextran sulfate in LDL apheresis
  • Valsartan/sacubitril
  • Aliskiren

Inform your physician about the drugs you take, including over-the-counter medications, prescribed drugs, supplements, and vitamins.

This is not a complete list of drug interactions. Approach your physician or pharmacist for more details.

The effects of certain medications can change if you consume different medications or herbal products simultaneously. This can build your risk for side effects or may cause your drugs not to work effectively. These interactions are conceivable, yet don’t generally happen. Your physician or pharmacist can prevent or oversee interactions by changing how you utilize your prescriptions or by close checking.

While utilizing this drug, don’t start, stop, or change the dose of other medicines you are using without your physician’s advice. 

Symptoms of overdose may include the following: 

  • Hypokalemia
  • Hyponatremia
  • Cramps
  • Mental confusion
  • Sleepiness
  • Dizziness
  • Vomiting
  • Nausea
  • Hypotension

Seek medical help immediately.

Available Brands:

  • Peripil Plus
  • Preterax
  • Coversyl Plus
  • Bi-Preterax

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