Pentobarbital is a barbiturate mainly used as a sedative and hypnotic. Its pharmacologic action is thought to be related to its ability to increase GABA activity by changing GABA receptor-mediated inhibitory synaptic impulses.

Use this medication precisely as recommended by your physician. Follow the prescription of your doctor carefully.

The medication dose given by your physician is based on your health conditions, other medications or food supplements taken, and your reaction to the treatment. To diminish risks for adverse effects, do not increase your dosage, thus take it regularly, or take it as instructed by your physician. Adverse events may still happen even at usual prescription dosages.

If your physician requests you to use this drug consistently, take it regularly to get the most benefits from it. To make you remember it better, take it at a fixed time every day.

Your doctor may need to modify your dosages to ease your symptoms or if you develop adverse reactions.

Pentobarbital is used in the following conditions:

  • Hypnotic
  • Sedation

This medicine may be recommended for different uses. Approach your physician or pharmacist for more information.

Do not use Pentobarbital in people with the following conditions:

  • Bronchopneumonia
  • Severe pulmonary impairment
  • History of porphyria
  • Addiction to sedative and hypnotics
  • Concomitant sodium oxybate

Pentobarbital may have the following side effects:

  • Drowsiness
  • Somnolence
  • Dizziness
  • Anxiety
  • Insomnia
  • Hypotension
  • Apnea
  • Respiratory depression
  • Bronchospasm
  • Laryngospasm
  • Bradycardia
  • Central Nervous System depression
  • Physical and psychological dependence
  • Psychiatric disturbance
  • Confusion
  • Hallucinations
  • Nightmares
  • Thinking abnormality
  • Syncope
  • Hyperkinesias
  • Ataxia
  • Agitation
  • Nervousness
  • Nausea
  • Vomiting
  • Constipation
  • Pain at injection site

Potentially Fatal: 

  • Stevens-Johnson syndrome

Keep in mind that your physician has recommended this drug since he or she has known that the advantage to you is more significant than the risk of adverse reactions. Many individuals utilizing this medicine don’t have serious side effects.  

A severe allergy to this medication is uncommon. In any case, seek emergency medical help if you see any manifestations of a serious allergic response, including a rash, tingling or swelling particularly of the face or tongue or throat, dizziness or difficulty in breathing.

This is not a complete list of side effects. If you see other effects not recorded above, contact your physician or pharmacist.

Take extra caution in patients with the following medical conditions:

  • Mentally depressed
  • Acute and chronic pain
  • Hepatic and renal impairment
  • Parenteral admin to patients with hypertension
  • Hypotension
  • Cardiovascular or pulmonary disease
  • Too rapid IV administration may result in respiratory depression, apnea, laryngospasm, or vasodilation with fall in blood pressure
  • Pregnancy
  • Lactation
  • Elderly

Prior in taking this medicine, tell your physician or pharmacist if you have allergies or other hypersensitivity reactions with the drug. This drug may contain inert ingredients which can cause unfavorable side effects or different issues. Talk with your pharmacist for more information.


Pentobarbital may interact with the following medicines:

  • Central Nervous System depressants
  • Monoamine oxidase Inhibitors
  • Phenytoin
  • Carbamazepine
  • Valproic acid
  • Anticoagulants
  • Corticosteroids
  • Griseofulvin
  • Doxycycline
  • Hormonal contraceptives

Potentially Fatal:

  • Sodium oxybate

Inform your physician about the drugs you take including over-the-counter medications, prescribed drugs, supplements and vitamins.

This is not a complete list of drug interactions. Approach your physician or pharmacist for more details.

The effects of certain medications can change if you consume different medications or herbal products simultaneously. This can build your risk for side effects or may cause your drugs not to work effectively. These interactions are possible, yet don’t generally happen. Your physician or pharmacist can prevent or oversee interactions by changing how you utilize your prescriptions or by close checking.

While utilizing this drug, don’t start, stop, or change the dose of other medicines you are using without your physician’s advice.



  • Unsteady gait
  • Slurred speech
  • Sustained nystagmus 


  • Confusion
  • Poor judgment
  • Irritability
  • Insomnia
  • Somatic complaints

If an overdose is suspected, call your health care provider immediately.

Available brands:

  • Nembutal

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