PENTAERYTHRITYL TETRANITRATE

Pentaerythrityl Tetranitrate dilates blood vessels by releasing nitric oxide, which activates guanylate cyclase in vascular smooth muscle cells, inducing relaxation. It also has a coronary vasodilator effect, which enhances regional coronary blood flow to ischemic areas, allowing more oxygen to reach the myocardium.

Use this medication precisely as recommended by your physician. Follow the prescription of your doctor carefully.

The medication dose given by your physician is based on your health conditions, other medications or food supplements taken, and your reaction to the treatment. To diminish risks for adverse effects, do not increase your dosage, thus take it regularly, or take it as instructed by your physician. Adverse events may still happen even at usual prescription dosages.

If your physician requests you to use this drug consistently, take it regularly to get the most benefits from it. To make you remember it better, take it at a fixed time every day.

Your doctor may need to modify your dosages to ease your symptoms or if you develop adverse reactions.

Uses

Pentaerythrityl Tetranitrate is used in the following conditions:

Angina pectoris

This medicine may be recommended for different uses. Approach your physician or pharmacist for more information.

Warnings

Do not use Pentaerythrityl Tetranitrate in people with the following conditions:

Severe hypotension
Heart failure
Marked anemia
Hypertrophic obstructive cardiomyopathy
Patients with cerebral hemorrhage or head trauma
Low cardiac output secondary to hypovolemia
Inferior myocardial infarction with right ventricular involvement
Raised intracranial pressure

Side Effects

Pentaerythrityl Tetranitrate may have the following side effects:

Flushing of the face
Dizziness
Tachycardia
Throbbing headache
Tolerance

Large dose:

Vomiting
Restlessness
Hypotension
Syncope
Rarely cyanosis
Methemoglobinemia
Impaired respiration
Bradycardia
Nausea
Urinary and fecal incontinence
Abdominal pain
Apprehension
Weakness
Vertigo

Potentially Fatal:

Paradoxical bradycardia
Impaired respiration
Collapse

Keep in mind that your physician has recommended this drug since he or she has known that the advantage to you is more significant than the risk of adverse reactions. Many individuals utilizing this medicine don’t have serious side effects.

A severe allergy to this medication is uncommon. In any case, seek emergency medical help if you see any manifestations of a serious allergic response, including a rash, tingling or swelling particularly of the face or tongue or throat, dizziness or difficulty in breathing.

This is not a complete list of side effects. If you see other effects not recorded above, contact your physician or pharmacist.

Precautions

Precautions

Take extra caution in patients with the following medical conditions:

Severe hepatic or renal impairment
Hypothyroidism
Malnutrition
Hypothermia
Cerebrovascular disease
Lung disease or cor pulmonale
Pregnancy
Lactation
Glaucoma
Mitral valve prolapse
Cardiac tamponade
Syncope

Prior in taking this medicine, tell your physician or pharmacist if you have allergies or other hypersensitivity reactions with the drug. This drug may contain inert ingredients which can cause unfavorable side effects or different issues. Talk with your pharmacist for more information.

Interactions

Pentaerythrityl Tetranitrate may interact with the following medicines:

Dihydroergotamine
ACE inhibitors

Potentially Fatal:

Calcium channel blockers
Antihypertensives
Phenothiazines
Tricyclic antidepressants
Alcohol

Inform your physician about the drugs you take including over-the-counter medications, prescribed drugs, supplements and vitamins.

This is not a complete list of drug interactions. Approach your physician or pharmacist for more details.

The effects of certain medications can change if you consume different medications or herbal products simultaneously. This can build your risk for side effects or may cause your drugs not to work effectively. These interactions are possible, yet don’t generally happen. Your physician or pharmacist can prevent or oversee interactions by changing how you utilize your prescriptions or by close checking.

While utilizing this drug, don’t start, stop, or change the dose of other medicines you are using without your physician’s advice.

Overdose & Brands

Symptoms of overdose may include the following:

Syncope
Hypotension

If an overdose is suspected, call your health care provider immediately.

Available brands:

Duotrate
Pentylan
Peritrate