Paracetamol is a pain reliever and a fever reducer.

Phenylpropanolamine Hydrochloride is mainly used as a nasal decongestant.

Chlorpheniramine maleate is an antihistamine used to treat sneezing, itching, watery eyes, and runny nose caused by allergies or the common cold.

For the relief of nasal catarrh (build up of mucus), nasal congestion, watery eyes, sneezing, fever, body pains and headache associated with the common cold, influenza, acute upper respiratory tract infections and upper respiratory inflammation with allergic component, e.g., allergic rhinitis and sinusitis.

Use with caution in patients with high blood pressure, toxic goiter, benign prostatic hypertrophy, heart rate irregularity, glaucoma and in those taking antidepressants.

Patients with heart disease and uncontrolled/untreated high blood pressure should consult a physician prior to taking this medicine.

Administration of paracetamol to patients with kidney or liver impairment may result in accumulation of chemicals harmful to the liver.

Antihistamines may cause drowsiness, dizziness and weakness; patients should observe caution while driving or performing other tasks requiring mental alertness.

Nervousness, restlessness, insomnia, dizziness, lassitude, muscular weakness, headache, nausea and drowsiness may occur with usual doses of phenylpropanolamine or chlorphenamine maleate.

Phenylpropanolamine may cause increased blood pressure, tightness of the chest, premature heart contractions and fast heartbeat (tachycardia).

Antihistamines may cause epigastric distress, diarrhea or constipation, vomiting and hypersensitivity reactions including contact dermatitis.

Paracetamol is relatively nontoxic in therapeutic doses; however, skin rash, accumulation of fluid in the throat and rarely, serious allergic (anaphylactoid) reactions, blood disorder (agranulocytosis), low white blood cell count (leukopenia) and deficiency of all three cellular components of the blood (red cells, white cells, and platelets), also known as pancytopenia, may occur with large doses.


Administer with caution to patients with glaucoma, prostatic hypertrophy, hyperthyroidism, cardiovascular disorders, diabetes mellitus, urinary retention, increased intraocular pressure and stenosing peptic ulcer.

Antihistamines are not recommended in patients with bronchial asthma because their drying effects may thicken mucus secretions and impair expectoration.

Administer paracetamol with caution to patients with preexisting anemia since cyanosis may not be apparent despite dangerously high blood concentrations of methemoglobin.

Paracetamol may cause allergic-type reactions eg, anaphylaxis in susceptible individuals. Discontinue use if hypersensitivity reactions occur.



Phenylpropanolamine should not be administered concomitantly with MAO inhibitors, rauwolfia alkaloids, tricyclic antidepressants, ganglionic blocking agents and halogenated hydrocarbon general anesthetics.

Antihistamines have additive effects with central nervous system (CNS) depressants such as alcohol, hypnotics, sedatives and tranquilizers, but may diminish the actions of oral anticoagulants.

Concomitant administration of paracetamol and phenothiazine may cause severe hypothermia.

If overdose is suspected, contact a poison control center or emergency room right away.

Available brands:

  • Nafarin-A Reformulated (UAP)
  • Neo-Bromexan Forte (Medi-Rx)
  • Sinutab Extra-Strength (Johnson & Johnson)

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