Paracetamol relieves pain and helps lower fever. Caffeine helps to increase the pain relief provided paracetamol and enhances alertness.

Symptomatic treatment of mild to moderate pain and fever in conditions such as headache, toothache and period pains.

Do not take Paracetamol + Caffeine if you are:

  • Allergic to paracetamol, caffeine or any of the product’s other ingredients
  • under 15 years of age or weigh less than 50 kilograms

Do not take any other medicine containing paracetamol while taking Paracetamol + Caffeine.

Do not take Paracetamol + Caffeine if you have a drinking problem (alcoholic) or liver damage.

Like all medicines, Paracetamol + Caffeine can sometimes cause side effects:

  • Blood and lymphatic system disorders
  • Very rare: Thrombocytopenia (low levels of blood platelets), agranulocytosis (low levels of white blood cells)
  • Immune system disorders
  • Rare: Anaphylactic reaction, allergic dermatitis, rash, angioedema, Stevens-Johnson syndrome, toxic epidermal necrolysis
  • Psychiatric disorders. Common: Insomnia, restlessness, anxiety
  • Nervous system disorders. Common: Nervousness, dizziness, headache
  • Cardiac disorders. Not known: Palpitations, tachycardia (heart beating too fast)
  • Respiratory, thoracic and mediastinal disorders. Very rare: Bronchospasm
  • Gastrointestinal disorders. Common: Gastrointestinal disorder
  • Very rare: liver function and enzyme abnormality (symptoms of liver damage)


Check with your doctor before taking this medicine if you:

  • Suffer from kidney or liver problems (including Gilbert’s syndrome) as the dose you need to take may need to be reduced
  • Have hepatitis
  • Suffer from Glucose-6-phosphatehydrogenase enzyme deficiency
  • Suffer from hemolytic anaemia (a form of anaemia caused by a breakdown of red blood cells)
  • Are an alcoholic or are recovering from alcoholism
  • Suffer from asthma and are sensitive to aspirin
  • Are dehydrated or suffer from chronic malnutrition
  • Have gout
  • Suffer from hyperthyroidism
  • Have arrhythmia (irregular heartbeat)



Talk to your pharmacist or doctor before you take Paracetamol + Caffeine if you are taking any medication, especially:

  • Clozapine (used to treat e.g. schizophrenia)
  • Beta-blockers such as atenolol, metoprolol, oxeprenolol or propranolol (used to treat high blood pressure and heart conditions)
  • Disulfiram (used in the treatment of alcoholism)
  • Fluvoxamin, monoamine oxidase inhibitors and litium (used to treat anxiety, depression and other psychological conditions) Diazepam (used to treat anxiety or as a sedative)
  • St. John’s wort (used to treat mild forms of depression)
  • Phenylpropanolamine and ephedrine (decongestants) or theophylline (for asthma)
  • Other medicines containing paracetamol
  • Colestyramine (used to treat high cholesterol levels and reduce the amount of fat in the blood)
  • Metoclopramide and domperidone (used to control feeling sick or being sick).
  • Anticoagulants taken by mouth (used to prevent the blood from clotting) Dipyridamole (often used during hospital tests for heart conditions)
  • Methoxsalen (used to treat the skin condition psoriasis)
  • Carbamazapine, phenobarbitol, phenytoin, stiripentol and lamotrigine (used to treat epilepsy)
  • Levothyroxine (used to treat thyroid conditions)
  • Pipermidic acid (used to treat infections)
  • Probenecid (used to treat gout)
  • Salicylamide (used to treat fever or mild pain)
  • Isoniazid (used to treat tuberculosis)
  • Zidovudine (used to treat HIV).
  • Mexiletine (used to treat heart arrhythmias)
  • Chloramphenicol, ciprofloxacin, norfloxacin, enoxacin, rifampicin (antibiotics)

The results of laboratory tests on uric acid and blood sugar may be affected by paracetamol.


If overdose is suspected, bring the victim to the nearest hospital right away.


Available brand:

  • Rexidol Forte (Unilab Consumer Health)

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