PANJECXONE

Do not use Panjecxone in people with the following conditions:

• Hypersensitivity: Ceftriaxone should not be used in individuals who have a known hypersensitivity or allergy to ceftriaxone or any other cephalosporin antibiotics. Allergic reactions to ceftriaxone can range from mild rash to severe, life-threatening reactions like anaphylaxis.
• Previous severe hypersensitivity: Ceftriaxone should be avoided in individuals who have experienced a severe hypersensitivity reaction, such as anaphylaxis, to any other beta-lactam antibiotics, including penicillins or carbapenems. Cross-reactivity between ceftriaxone and other beta-lactam antibiotics can occur in these cases.
• Hyperbilirubinemic neonates: Ceftriaxone is contraindicated in neonates (newborn babies) who have hyperbilirubinemia, a condition characterized by high levels of bilirubin in the blood. Ceftriaxone can displace bilirubin from binding sites on proteins, which can lead to a condition called bilirubin encephalopathy or kernicterus, characterized by brain damage due to elevated levels of bilirubin.

Panjecxone may have the following side effects:

• Gastrointestinal effects: The most common side effects of ceftriaxone are related to the gastrointestinal system. These can include diarrhea, nausea, vomiting, abdominal pain, and changes in bowel movements. It’s important to stay well-hydrated and inform your healthcare provider if these symptoms become severe or persistent.
• Allergic reactions: Although rare, some individuals may experience allergic reactions to ceftriaxone. These can range from mild rashes and itching to more severe reactions like hives or anaphylaxis. Seek immediate medical attention if you experience any signs of an allergic reaction.
• Injection site reactions: Ceftriaxone is usually given as an intravenous or intramuscular injection, and some individuals may experience pain, redness, swelling, or tenderness at the injection site. Inform your healthcare provider if you notice any unusual reactions at the injection site.
• Changes in blood tests: Ceftriaxone can occasionally affect certain laboratory tests, such as liver function tests, kidney function tests, and blood cell counts. Your healthcare provider will monitor these parameters during treatment.
• Other potential side effects: Although less common, ceftriaxone may cause other side effects such as headache, dizziness, fatigue, fever, or a metallic taste in the mouth.

Keep in mind that your physician has recommended this drug since he or she has known that the advantage to you is more noteworthy than the risk of adverse reactions. Many individuals utilizing this medicine don’t have serious side effects.

A serious allergy to this medication is uncommon. In any case, seek emergency medical help if you see any manifestations of a serious allergic response, including a rash, tingling or swelling particularly of the face or tongue or throat, dizziness or difficulty in breathing.

This is not a complete list of side effects. If you see other effects not recorded above, contact your physician or pharmacist.

Precautions

Take extra caution in patients with the following medical conditions:

• Allergies: Inform your healthcare provider about any known allergies or previous adverse reactions to ceftriaxone or any other cephalosporin antibiotics. A history of allergic reactions to other beta-lactam antibiotics, such as penicillins or carbapenems, should also be disclosed. This information will help your healthcare provider determine if ceftriaxone is safe for you.
• Kidney and liver function: Ceftriaxone is primarily eliminated from the body through the kidneys. If you have impaired kidney function, your healthcare provider may need to adjust the dose of ceftriaxone accordingly. Similarly, individuals with severe liver disease may require dose adjustments due to the potential impact on drug metabolism.
• Gallbladder disease: Ceftriaxone has been associated with the formation of gallstones, particularly in individuals with a history of gallbladder disease. Inform your healthcare provider if you have a history of gallbladder issues or if you experience symptoms such as abdominal pain, jaundice (yellowing of the skin or eyes), or changes in bowel habits.
• Bleeding disorders: Ceftriaxone may affect blood clotting factors, so it should be used with caution in individuals with bleeding disorders or those taking medications that can increase the risk of bleeding, such as anticoagulants.
• Pregnancy and breastfeeding: Ceftriaxone is generally considered safe to use during pregnancy and breastfeeding. However, it’s important to discuss your pregnancy or breastfeeding status with your healthcare provider to evaluate the potential risks and benefits.
• Interactions with other medications: Inform your healthcare provider about all medications, supplements, or herbal products you are taking, as ceftriaxone may interact with certain medications.

Prior to taking this medicine, tell your physician or pharmacist if you are allergic to it, or if you have some other hypersensitivities. This drug may contain inert ingredients which can cause unfavorable side effects or different issues. Talk with your pharmacist for more information.

Interactions

Panjecxone may interact with the following medicines:

• Calcium-containing products: Ceftriaxone should not be mixed or administered simultaneously with calcium-containing products (e.g., calcium-containing intravenous solutions or oral calcium supplements) in neonates (infants less than 28 days old) due to the risk of forming ceftriaxone-calcium precipitates in the lungs and kidneys. This interaction does not apply to older children or adults.
• Other medications affecting blood clotting: Ceftriaxone can affect blood clotting factors, so caution should be exercised when using it with other medications that can increase the risk of bleeding, such as anticoagulants (e.g., warfarin) or antiplatelet drugs (e.g., aspirin, clopidogrel). Your healthcare provider may need to monitor your blood clotting parameters more closely.
• Probenecid: Probenecid, a medication used to treat gout, can increase the levels of ceftriaxone in the blood by reducing its elimination. Your healthcare provider may need to adjust the dose of ceftriaxone if you are taking probenecid.
• Aminoglycoside antibiotics: When ceftriaxone is used in combination with certain aminoglycoside antibiotics (e.g., gentamicin), there is a potential interaction that can increase the risk of kidney damage. Close monitoring of kidney function is necessary when using these medications together.
• Other medications: Inform your healthcare provider about all medications, supplements, or herbal products you are taking, as ceftriaxone may interact with some medications. This includes medications that can affect kidney function or those that may be affected by changes in blood clotting.

Inform your physician about the drugs you take including over-the-counter medications, prescribed drugs, supplements and vitamins.

This is not a complete list of drug interactions. Approach your physician or pharmacist for more details.

The effects of certain medications can change if you consume different medications or herbal products simultaneously. This can build your risk for side effects or may cause your drugs not to work effectively. These interactions are conceivable, yet don’t generally happen. Your physician or pharmacist can prevent or oversee interactions by changing how you utilize your prescriptions or by close checking.

While utilizing this drug, don’t start, stop, or change the dose of other medicines you are using without your physician’s advice.

If you suspect an overdose, contact your doctor right away.

Available Brands:

• Panjecxone