COMMON BRAND NAME(S): Eloxatin
GENERIC NAME(S): OXALIPLATIN
Description: Oxaliplatin, a platinum-containing complex similar to cisplatin, is an alkylating agent which inhibits DNA replication and transcription, resulting in cell death.
Pharmacokinetics:
Distribution: Vd: 440 L; protein binding: >90% primarily albumin and gamma globulin (irreversible binding to platinum). Also binds irreversibly to red blood cells.
Metabolism: Rapidly and extensively metabolised to active and inactive compounds.
Excretion: Via urine (approx 54%); faeces (approx 2%).