OXALIPTALIN INTRAVENOUS

COMMON BRAND NAME(S): Eloxatin

GENERIC NAME(S): OXALIPLATIN

 

Description: Oxaliplatin, a platinum-containing complex similar to cisplatin, is an alkylating agent which inhibits DNA replication and transcription, resulting in cell death.

Pharmacokinetics:

Distribution: Vd: 440 L; protein binding: >90% primarily albumin and gamma globulin (irreversible binding to platinum). Also binds irreversibly to red blood cells.

Metabolism: Rapidly and extensively metabolised to active and inactive compounds.

Excretion: Via urine (approx 54%); faeces (approx 2%).

  • Used to treat
    • Advanced cancer of the colon and rectum.
      • Used in combination with other medications to slow or stop cancer cell growth
      • May also be used to treat other types of cancer (such as testicular cancer).

How to use oxaliplatin intravenous

This medication is usually given by infusion into a vein over at least 2 hours by a health care professional; usually given every 2 weeks along with other medications (e.g., 5-fluorouracil and leucovorin). Duration and dosage will be determined by your medical condition and its response to the medication

May rarely cause a severe (possibly fatal) allergic reaction within minutes after a dose. Get immediate medical help if you develop any signs of an allergic reaction (such as rash, itching, swelling, trouble breathing, swelling of throat, dizziness).

 

  • Minor side effects (if these symptoms persist or worsen, inform your doctor)
    • Diarrhea, changes in taste, mouth sores, nosebleeds, tiredness, headache, dizziness, or trouble sleeping may occur
    • Nausea and vomiting may be severe
    • Eating small frequent meals, not eating before treatment, or activity limitation may help reduce some of these effects. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.
  • Temporary hair loss may infrequently occur. Normal hair growth should return after the end of treatment
  • Serious side effects (inform your doctor immediately)
    • pain/redness/swelling at the injection site, easy or unusual bruising/bleeding, mental/mood changes (e.g., depression), signs of too much body water loss (e.g., decreased urination, increased thirst, dry mouth), muscle cramps, weakness, pain/redness/swelling of the arms/legs, groin/calf pain, fainting.
    • May sometimes affect how your nerves work (peripheral neuropathy)
      • sensitivity to cold, trouble breathing/swallowing/speaking, jaw tightness, strange feeling in your tongue, eye pain, chest pressure, numbness/tingling/”pins and needles” sensation of the hands/feet/mouth/throat
    • dry cough, shortness of breath, chest pain, black stools, vomit that looks like coffee grounds, vision changes (such as blurred vision, temporary vision loss), seizures, sudden confusion.
  • Can lower your body’s ability to fight an infection. Inform your doctor immediately if you develop any signs of an infection such as fever, chills, or persistent sore throat.
  • Severe allergic reactions are rare. Get immediate medical help if you notice the following:
    • Rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

Precautions:

  • Inform your doctor if you
    • Are allergic to the or to other platinum-containing products (e.g., cisplatin, carboplatin)
    • Have a history of kidney problems, blood disorders, bone marrow problems, nerve disorders
  • May cause vision changes. Do perform any activity that requires clear vision until you can perform such activities safely.
  • Do not have immunizations/vaccinations without your doctor’s consent, and avoid contact with persons who have recently received oral polio vaccine or flu vaccine inhaled through the nose. Frequent and proper handwashing is key to prevent the spread of infections
  • Exercise caution with sharp objects like razors and nail cutters, and avoid activities such as contact sports in order to lower your risk of getting cut, bruised, or injured
    • This medication is not recommended for use during pregnancy as it may harm an unborn baby. Consult your doctor for more information
    • Consult your doctor before breast-feeding due to the possible risk to the infant, breast-feeding while using this drug is not recommended.

 

Interactions:

Taking multiple drugs may affect how medications work and/or cause unwanted side effects. List down all the medications you are taking and inform your physician and pharmacist. Do not take, discontinue, or alter any dose of medications without prior approval of your physician.

  • Products that may interact with this medication Include:
    • Aminoglycosides (e.g., gentamicin, amikacin), amphotericin B, cyclosporine, nalidixic acid, nonsteroidal anti-inflammatory drugs (e.g., ibuprofen), tacrolimus, vancomycin.

Overdose:

If overdose is suspected, contact a poison control center or emergency room immediately.

Missed Dose

For the best possible benefit, it is important to receive each scheduled dose of this medication as directed. If you miss a dose, contact your doctor to establish a new dosing schedule.

Storage

Not applicable. This medication is given in a clinic and will not be stored at home.

 

Brands:

Available Brands:

Eloxatin [ sanofi-aventis ]                                                                                                    Henplatin [ Jiangsu Hengrui ]

Hospira Oxaliplatin [ Hospira ]                                                                                           Oxalee [ Biomedis Oncology ]

Oxapla [ Yuhan ]                                                                                                                   Oxavid [ Hovid ]

Oxitel [ Fresenius Kabi ]                                                                                                      Platinox [ Korea United Pharma ]

Sindoxplatin [ PPC ]                                                                                                             Zildox 50 [ Ambica ]

Also marketed as:

Meslatin [ Oncolife Corp ]                                                                                                  Oxalem [ Pharmachemie ]

Oxaplat [ Kalbe International Phils ]

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