Watsons Health


Omeprazole + sodium bicarbonate is a combination drug that is used in the treatment of peptic ulcer disease. It is composed of two drugs: omeprazole and sodium bicarbonate.

Omeprazole is a drug that is known as a proton-pump inhibitor. It inhibits the secretion of acid in the stomach by blocking the enzyme system of hydrogen and potassium adenosine triphosphate, otherwise known as the proton pump of the parietal cells of the stomach.

Sodium bicarbonate is a compound that can reduce stomach acid. It is used as an antacid for the treatment of heartburn, upset stomach and indigestion. It is quick-acting but is used only for temporary relief.

Omeprazole + sodium bicarbonate is used in the treatment of the following:

  • Duodenal ulcers
  • Gastric ulcers
  • Gastro-esophageal reflux disease (GERD)
  • Erosive esophagitis

Do not give Omeprazole + sodium bicarbonate in people with the following conditions:

Omeprazole + sodium bicarbonate may have the following side effects:


Take extra caution in patients with the following medical conditions:

  • Gastric malignancy
  • Atrophic gastritis
  • Gastric corpus biopsies
  • Bartter’s syndrome
  • Hypokalemia



Omeprazole + sodium bicarbonate may interact with the following medicines:

Symptoms of overdose may include the following:

  • Drowsiness
  • Blurred vision
  • Tachycardia
  • Nausea
  • Vomiting
  • Diaphoresis


 Available Brand:

  • Zegacid

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