Description: Olsalazine is a 5-aminosalicylic acid derivative which has anti-inflammatory properties. Pharmacokinetics:

Absorption: <3%; very little intact olsalazine is systemically absorbed. Time to peak: approx 1 hr.

Distribution: Protein binding, plasma: >99%.

Metabolism: Primarily via colonic bacteria to active drug.

Excretion: Half-life elimination: 56 min; primarily faeces.

  • Used in the treatment of ulcerative colitis, not for cure but to decrease symptoms such as stomach pain, diarrhea, and rectal bleeding caused by irritation/swelling of the colon/rectum
  • After an attack, it is used to increase the period between attacks.
  • It is a salicylate anti-inflammatory drug.
    • Believed to work by blocking prostaglandin production, a substance that may cause pain and swelling
  • Also used to treat Crohn’s disease.


How to use olsalazine

  • Always refer to your doctors instructions before taking this medication. Duration and dosage will be determined by your medical condition and its response to the medication. Make sure to take this mediciation in the prescribed amount and time period even after symptoms disappear. Discontinuing the medication before completion of treatment may cause incomplete treatment of condition. If Symptoms persist, consult your doctor.

Taken by mouth; To prevent upset stomach take with food or after meals; usually twice a day

    • Minor side effects (if these symptoms persist or worsen, inform your doctor)
      • Headache
      • Nausea
      • Vomiting
      • Loss of appetite may occur


    • Inform your doctor immediately if diarrhea occurs. A change of dose or anti-diarrheal medication might be needed


    • Serious side effects (inform your doctor immediately)
      • Sever stomach/abdominal pain
      • Pale stools
      • Unusual tiredness
      • Persistent nausea/vomiting
      • Change in the amount of urine
      • Dark urine
      • Yellowing eyes/skin
      • Signs of infection (e.g., fever, persistent sore throat)
      • Easy bruising/bleeding.


    • Severe allergic reactions are rare. Get immediate medical help if you notice the following:

    Rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

    • Precautions:
      • Inform your doctor if you
        • Are allergic to the medication or to aspirin or related drugs (salicylates such as mesalamine, NSAIDs such as ibuprofen, balsalazide, sulfasalazine) or if you have any other allergies
        • Have a history of asthma, growths in the nose (nasal polyps), kidney problems, liver problems, radiation treatment in the pelvic area


      • May cause stomach bleeding
        • Daily alcohol ingtake may increase your risk for stomach bleeding, especially in combination with this medication. Consult your doctor for more information


      • Similar to aspirin
        • Children and teenagers should the medication if they have the following without first consulting a doctor about Reye’s syndrome, a rare but serious illness.
          • Chickenpox
          • Flu
          • Any undiagnosed illness
          • Have just been given a live virus vaccine (e.g., varicella vaccine),


      • If you are planning to be pregnant or think you may be pregnant, discuss the risks and benefits of use with your doctor.


      • Consult your doctor before breast-feeding as this medication passes into breast milk and may cause unwanted effects on your baby



      Taking multiple drugs may affect how medications work and/or cause unwanted side effects. List down all the medications you are taking and inform your physician and pharmacist. Do not take, discontinue, or alter any dose of medications without prior approval of your physician.


      • Products that may interact with this medication Include:
        • Mercaptopurine
        • Do not use mesalamine medications taken by mouth while using olsalazine
      • Labratory tests that may be affected:

      Urine normetanephrine levels

    • Overdose: 

      If overdose is suspected, contact a poison control center or emergency room immediately.



      Do not take this medication unless prescribed by your physician


      Missed Dose

      As soon as you remember, take a regular dose or if the time of the next dose is near, wait for it before taking another dose and resume your usual schedule. Do not increase the dose to compensate for the missed dose.



      • Room temperature
      • Do not expose to light and moisture
      • Do not store in the bathroom
      • Keep all medications away from pets and children




      Available Brands:


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