COMMON BRAND NAME(S): Benicar
GENERIC NAME(S): OLMESARTAN MEDOXOMIL
Description: Olmesartan is a selective and competitive angiotensin II Type 1 (AT1) receptor antagonist that relaxes blood vessels, thereby lowering BP and increasing blood supply and oxygen to the heart.
Absorption: Bioavailability: Approx 26%. Time to peak plasma concentration: Approx 1-2 hr.
Distribution: Volume of distribution: 17 L. Plasma protein binding: ≤99%.
Metabolism: Olmesartan medoxomil undergoes ester hydrolysis in the GI tract to active form olmesartan.
Excretion: Mostly via faeces (50-65%) and urine (35-50%) both as olmesartan. Terminal half-life: Approx 10-15 hr.