Obinutuzumab - Uses Warnings Side Effects Precautions Overdose & Brands

OBINUTUZUMAB

Bivalirudin

Obinutuzumab is an anti-cancer drug that is also known as Type II anti-CD20 and recombinant humanized monoclonal antibody. After binding to CD20, this drug causes lysis of B lymphocytes by inducing direct cell death and by leading to antibody-dependent mobile cytotoxicity (ADCC) and antibody-dependent cell phagocytosis (ADCP). It additionally mediates complement dependent cytotoxicity.

It is used in the treatment of cancers, such as chronic lymphocytic leukemia, follicular lymphoma and marginal zone lymphoma.

Obinutuzumab should not be given to people with the following conditions:

  • Hypersensitivity to this drug including serum sickness
  • Those who just had live viral vaccines

Obinutuzumab may have some side effects such as the following:

  • Alopecia
  • Anemia
  • Anxiety
  • Arthralgia
  • Asthenia
  • Atrial fibrillation
  • Cardiac failure
  • Chest pain
  • Constipation
  • Cough
  • Depression
  • Diarrhea
  • Dyspepsia
  • Eczema
  • Extremities, back and bone pain
  • Fatigue
  • HBV reactivation leading to fulminant hepatitis and hepatic failure
  • Headache
  • Herpes zoster and herpes simplex virus infection
  • Hyper- or hypo-kalemia
  • Hypersensitivity reactions including serum sickness
  • Hypertension
  • Hyperuricemia
  • Hypoalbuminemia
  • Hypocalcemia
  • Hyponatremia
  • Hypophosphatemia
  • Hypotension
  • Increased AST or ALT
  • Increased serum creatinine
  • Influenza
  • Infusion related reactions
  • Insomnia
  • Leukopenia
  • Lung infection, pneumonia
  • Lymph node pain
  • Lymphopenia
  • Nasal congestion
  • Nasopharyngitis
  • Nausea
  • Neutropenia, thrombocytopenia, hemorrhage
  • Oropharyngeal pain
  • Pharyngitis
  • PML (rare)
  • Pruritus
  • Pyrexia
  • Rhinitis
  • Rhinorrhea
  • Sepsis
  • Serious bacterial, fungal and viral infections
  • Sinusitis
  • Tumor lysis syndrome
  • Upper respiratory tract infection
  • UTI

Precautions

Special precautions should be observed in people with the following conditions:

  • Patients with history or current serious infection especially hepatitis B virus (HBV) infection
  • Risk of tumor lysis syndrome (example high tumor burden, high lymphocyte count)
  • Cardiac and respiratory impairment
  • Kidney impairment
  • Pregnancy
  • Lactation

 

 

Interactions

Obinutuzumab may interact with the following medicines:

  • Antihypertensive agents
  • Anticoagulants, platelet inhibitors
  • Live vaccines

If you think you may have used Obinutuzumab more than the usual dose, seek medical help immediately.

Available Brands:

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