COMMON BRAND NAME(S): Aventyl, Pamelor
GENERIC NAME(S): NORTRIPTYLINE HCL
Description: Nortriptyline is a dibenzocycloheptadiene tricyclic antidepressant
Absorption: Time to peak plasma concentration: 7-8.5 hr.
Distribution: Crosses the placenta and distributed into breast milk. Volume of distribution: 21 L/kg. Plasma protein binding: 93-95%.
Metabolism: Primarily hepatic; undergoes extensive first-pass metabolism; converted to 10-hydroxynortriptyline (active).
Excretion: Via urine (as metabolites and small amounts of unchanged drug); faeces (small amounts). Elimination half-life: 28-31 hr.