NORETHISTERONE - Uses, Warnings, Side effects, Precautions


Norethisterone has the usual effects of a progestogen and transforms the endometrium from the secretory to the proliferative process. It prevents the secretion of pituitary gonadotropins, thus preventing ovulation and follicular maturation. In addition, the cervical mucus viscosity is increased and the endometrium is changed, resulting in decreased implantation and blocked penetration of sperm.

Use this medication precisely as recommended by your physician. Follow the prescription of your doctor carefully.

The medication dose given by your physician is based on your health conditions, other medications or food supplements taken, and your reaction to the treatment. To diminish risks for adverse effects, do not increase your dosage, thus take it regularly, or take it as instructed by your physician. Adverse events may still happen even at usual prescription dosages.

If your physician requests you to use this drug consistently, take it regularly to get the most benefits from it. To make you remember it better, take it at a fixed time every day.

Your doctor may need to modify your dosages to ease your symptoms or if you develop adverse reactions.

Norethisterone is used in the following conditions:

This medicine may be recommended for different uses. Approach your physician or pharmacist for more information.  

Do not use Norethisterone in people with the following conditions:

  • Known, suspected, or history of breast cancer or endometrial cancer
  • Active or recent arterial thromboembolic disease
  • Current or history of venous thromboembolism 
  • Angina pectoris
  • Undiagnosed vaginal bleeding
  • Porphyria
  • Benign or malignant hepatic tumour
  • Severe diabetes with vascular changes
  • Pathologically increased blood pressure
  • Hepatic impairment or disease 
  • Pregnancy

Norethisterone may have the following side effects:

  • Irregular menstrual bleeding
  • Breast cancer
  • Visual abnormalities 
  • Migraine
  • Depression
  • Decreased glucose tolerance
  • Venous thromboembolism 
  • Benign or malignant liver tumor
  • Nausea
  • Vomiting
  • Abdominal pain
  • Fatigue
  • Cholestatic jaundice
  • Hypersensitivity
  • Weight gain
  • Abnormal liver function test
  • Edema
  • Headache
  • Dizziness
  • Insomnia
  • Breast tenderness
  • Amenorrhea
  • Spotting
  • Decreased libido
  • Change in cervical secretions
  • Cervical erosion
  • Breast hypertrophy
  • Acne
  • Chloasma
  • Pruritus
  • Urticaria

Keep in mind that your physician has recommended this drug since he or she has known that the advantage to you is more significant than the risk of adverse reactions. Many individuals utilizing this medicine don’t have serious side effects.  

A severe allergy to this medication is uncommon. In any case, seek emergency medical help if you see any manifestations of a serious allergic response, including a rash, tingling or swelling particularly of the face or tongue or throat, dizziness or difficulty in breathing.

This is not a complete list of side effects. If you see other effects not recorded above, contact your physician or pharmacist.


Take extra caution in patients with the following medical conditions:

  • Risk factors for cardiovascular disease 
  • Venous thromboembolism 
  • Depression
  • Diabetes mellitus
  • Conditions that may be aggravated by fluid retention 
  • Smokers
  • Renal impairment
  • Lactation

Prior in taking this medicine, tell your physician or pharmacist if you have allergies  or other hypersensitivity reactions with the drug. This drug may contain inert ingredients which can cause unfavorable side effects or different issues. Talk with your pharmacist for more information.


Norethisterone may interact with the following medicines:

  • Barbiturates
  • Phenytoin
  • Carbamazepine
  • Griseofulvin
  • Felbamate
  • Ketoconazole
  • Erythromycin
  • Verapamil
  • Diltiazem
  • Ulipristal

Inform your physician about the drugs you take including over-the-counter medications, prescribed drugs, supplements and vitamins.

This is not a complete list of drug interactions. Approach your physician or pharmacist for more details.

The effects of certain medications can change if you consume different medications or herbal products simultaneously. This can build your risk for side effects or may cause your drugs not to work effectively. These interactions are possible, yet don’t generally happen. Your physician or pharmacist can prevent or oversee interactions by changing how you utilize your prescriptions or by close checking.

While utilizing this drug, don’t start, stop, or change the dose of other medicines you are using without your physician’s advice.

If an overdose is suspected, call your health care provider immediately.

Available brands:

  • Aygestin
  • Camila
  • Errin
  • Jolivette
  • Lyza
  • Nora-BE
  • Nor-QD
  • Ortho Micronor

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