Description: Nizatidine is a histamine H2-receptor antagonist that decreases gastric acid secretion, gastric volume and hydrogen ion concentration.


Absorption: Readily absorbed from the GI tract. Bioavailability: >70%; slightly increased by food. Time to peak plasma concentration: Approx 0.5-3 hr.

Distribution: Widely distributed; enters breast milk. Volume of distribution: 0.8-1.5 L/kg. Plasma protein binding: Approx 35%.

Metabolism: Partly hepatic. Converted to nizatidine N-2-oxide, nizatidine S-oxide, and N-2-monodesmethylnizatidine (60% of the activity).

Excretion: Via urine (>90%), in part by active tubular secretion, w/in 12 hr, approx 60% as unchanged drug; faeces (<6%). Elimination half-life: 1-2 hr.

  • Used for
    • Ulcers of the stomach and intestines and prevents it from recurring after healing
    • Also used to treat certain stomach and throat (esophagus) problems such as erosive esophagitis, gastroesophageal reflux disease-GER by decreasing the amount of acid your stomach makes. It relieves symptoms such as cough that doesn’t go away, stomach pain, heartburn, and difficulty swallowing


  • Nizatidine belongs to a class of drugs known as H2 blockers.


  • May also be used to treat other stomach/intestinal problems caused by too much stomach acid.


How to use nizatidine

  • Always refer to your doctors instructions before taking this medication. Duration and dosage will be determined by your medical condition and its response to the medication. Make sure to take this mediciation in the prescribed amount and time period even after symptoms disappear. Discontinuing the medication before completion of treatment may cause incomplete treatment of condition. If Symptoms persist, consult your doctor


  • Taken by mouth; With or without food; usually once or twice a day or as directed by your physician;

If medication comes in a liquid form, shake the bottle well before intake. Use a special measuring device/spoon for every dosage and not household spoon to avoid incorrect dose.

    • Minor side effects (if these symptoms persist or worsen, inform your doctor)
      • Headache or diarrhea


    • Serious side effects (inform your doctor immediately)
      • nausea/vomiting that doesn’t stop, loss of appetite, stomach/abdominal pain, yellowing eyes/skin, dark urine, confusion, breast swelling/soreness in males, easy bruising/bleeding, signs of infection (such as sore throat that doesn’t go away, fever, chills), fast/pounding heartbeat, unusual tiredness.


    • Severe allergic reactions are rare. Get immediate medical help if you notice the following:
      • Rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing
    • Precautions:
      • Inform your doctor
        • Allergy to the medication or to other H2 blockers (cimetidine, famotidine, ranitidine) or any allergies
        • Medical History of immune system problems, kidney problems, liver problems, certain lung diseases (such as chronic obstructive pulmonary disease-COPD), other stomach problems (such as tumors)


      • Some symptoms may actually be signs of a more serious condition. Get medical help right away if you have:
        • heartburn with lightheadedness/sweating/dizziness, chest/jaw/arm/shoulder pain (especially with shortness of breath, unusual sweating), unexplained weight loss.


      • Should only be used when there is a clear need during pregnancy as it may harm an unborn baby. If you are planning to be pregnant or think you may be pregnant, discuss the risks and benefits of use with your doctor.


      • Consult your doctor before breast-feeding as this medication passes into breast milk and may cause unwanted effects on your baby




      Taking multiple drugs may affect how medications work and/or cause unwanted side effects. List down all the medications you are taking and inform your physician and pharmacist. Do not take, discontinue, or alter any dose of medications without prior approval of your physician.


      • Products that may interact with this medication include:
        • atazanavir, dasatinib, delavirdine, certain azole antifungals (such as itraconazole, ketoconazole), pazopanib, among others.


      • Do not take this medication with other products that contain nizatidine or other H2 blockers (cimetidine, famotidine, ranitidine).


      • Labratory tests that may be affected:

      urine protein tests

    • If overdose is suspected, contact a poison control center or emergency room right away.Missed Dose

      If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and As soon as you remember, take a regular dose or if the time of the next dose is near, wait for it before taking another dose and resume your usual schedule. Do not increase the dose to compensate for the missed dose.



      • Room temperature
      • Do not expose to light and moisture
      • Do not store in the bathroom
      • Keep all medications away from pets and children




      Also marketed as:

      Axid [ GlaxoSmithKline ]

    • Nolcer [ Euro-Med ]

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