COMMON BRAND NAME(S): Axid
GENERIC NAME(S): NIZATIDINE
Description: Nizatidine is a histamine H2-receptor antagonist that decreases gastric acid secretion, gastric volume and hydrogen ion concentration.
Pharmacokinetics:
Absorption: Readily absorbed from the GI tract. Bioavailability: >70%; slightly increased by food. Time to peak plasma concentration: Approx 0.5-3 hr.
Distribution: Widely distributed; enters breast milk. Volume of distribution: 0.8-1.5 L/kg. Plasma protein binding: Approx 35%.
Metabolism: Partly hepatic. Converted to nizatidine N-2-oxide, nizatidine S-oxide, and N-2-monodesmethylnizatidine (60% of the activity).
Excretion: Via urine (>90%), in part by active tubular secretion, w/in 12 hr, approx 60% as unchanged drug; faeces (<6%). Elimination half-life: 1-2 hr.