Nivolumab is a human immunoglobulin G4 (IgG4) monoclonal antibody that binds to the PD-1 receptor, a negative immunoregulatory protein. This activates the immune reaction against tumor cells.

Use this medication precisely as recommended by your physician. Follow the prescription of your doctor carefully.

The medication dose your physician has given is based on your condition, other medications or food supplements you may take, and your reaction to treatment. To diminish your risks for adverse effects, don’t increase your dosage, take it regularly, or take it as instructed by your physician. Adverse events may still happen even at usual prescription dosages.

If your physician requests you to use this drug consistently, use it regularly to get the most benefits from it. To make you remember it better, take it at a fixed time every day.

Your doctor may need to modify your dosages to ease your symptoms or if you develop adverse reactions.

If you have any inquiries with regards to information, ask your physician or pharmacist. 

Nivolumab is used in the following conditions:

  • Hepatocellular carcinoma
  • Spread of colorectal cancer 
  • Recurrence of classical Hodgkin’s lymphoma
  • Classical Hodgkin’s lymphoma refractory
  • Metastasis urothelial cancer
  • Metastasis squamous cell carcinoma of the neck and head
  • Spread of non-small cell lung cancer 
  • Melanoma with metastasis
  • Urothelial cancer that has spread locally
  • Squamous cell carcinoma of the neck and head that has spread locally
  • Non-small cell lung cancer that has spread locally

This medicine may be recommended for different uses. Approach your physician or pharmacist for more information.

Do not use Nivolumab in people with the following conditions:

  • Hypersensitivity

Nivolumab may have the following side effects:

  • Hypertension
  • Erythema
  • Vitiligo
  • Pruritus
  • Rash
  • Upper respiratory tract infection
  • Urinary tract infection
  • Peripheral nerve palsy
  • Neuritis
  • Peripheral neuropathy
  • Headache
  • Myopathy
  • Arthralgia
  • Back Pain
  • Musculoskeletal pain
  • Hypomagnesaemia
  • Hypocalcaemia
  • Hyperkalaemia
  • Hyponatraemia
  • Reduced appetite
  • Peripheral edema
  • Increased cholesterol, triglycerides, lipase, serum amylase
  • Febrile response
  • Weakness
  • Malaise 
  • Fatigue
  • Stomatitis
  • Intestinal perforation
  • Abdominal pain
  • Vomiting
  • Constipation
  • Nausea
  • Thrombocytopenia
  • Leucopenia
  • Anemia
  • Lymphocytopenia
  • Extreme infusion-related responses
  • Uveitis
  • Demyelination
  • Auto-immune neuropathy
  • Immune-mediated nephritis
  • Hypophysitis
  • High level bilirubin, alkaline phosphatase, AST, AL
  • Diabetic ketoacidosis
  • Type 1 diabetes mellitus
  • Lack of adrenal

Potentially Fatal:

  • Rhabdomyolysis
  • Myocarditis
  • Myositis
  • Pulmonary embolism
  • Interstitial lung disease or pneumonitis
  • Pneumonia
  • Thyroid dysfunction
  • Hypophysitis
  • Hepatitis
  • Colitis or diarrhea
  • Immune-mediated encephalitis
  • Renal failure
  • Dyspnoea
  • Neutropaenia
  • Toxic epidermal necrolysis
  • Stevens-Johnson syndrome

Keep in mind that your physician has recommended this drug since he or she has known that the advantage to you is more noteworthy than the risk of adverse reactions. Many individuals utilizing this medicine don’t have serious side effects. 

A serious allergy to this medication is uncommon. In any case, seek emergency medical help if you see any manifestations of a serious allergic response, including a rash, tingling or swelling particularly of the face or tongue or throat, dizziness or difficulty in breathing.

This is not a complete list of side effects. If you see other effects not recorded above, contact your physician or pharmacist.

Take extra caution in patients with the following medical conditions:

  • Lactation
  • Pregnancy
  • Children
  • Mild to extreme hepatic impairment
  • a recipient of hematopoietic stem cell transplant
  • Health problems that need systemic immunosuppression
  • A severe illness or a poor prognosis
  • Interstitial lung disease with symptoms
  • Melanoma of the eye (uvea)
  • Patients who have a background of active auto-immune illness or active brain metastases

When used to treat neck and head cancers, people with salivary gland carcinoma or nasopharyngeal cancer are also at risk.

Prior to taking this medicine, tell your physician or pharmacist if you are allergic to it or if you have some other hypersensitivities. This drug may contain inert ingredients, which can cause unfavorable side effects or different issues. Talk with your pharmacist for more information.


Nivolumab may interact with the following medicines:

  • Immunosuppressants

Inform your physician about the drugs you take, including over-the-counter medications, prescribed drugs, supplements and vitamins.

This is not a complete list of drug interactions. Approach your physician or pharmacist for more details.

The effects of certain medications can change if you consume different medications or herbal products simultaneously. This can build your risk for side effects or may cause your drugs not to work effectively. These interactions are conceivable, yet don’t generally happen. Your physician or pharmacist can prevent or oversee interactions by changing how you utilize your prescriptions or by close checking.

While utilizing this drug, don’t start, stop, or change the dose of other medicines you are using without your physician’s advice. 

If an overdose is suspected, call your health care provider immediately.

Available Brands:

  • Opdivo

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