NITAZOXANIDE

COMMON BRAND NAME(S): Alinia

GENERIC NAME(S): NITAZOXANIDE

Description: Nitazoxanide is an antiprotozoal agent

Pharmacokinetics:

Absorption: Absorbed from the GI tract (oral). Extent of absorption enhanced with food; peak plasma concentrations of tizoxanide and glucuronide metabolite after 1-4 hr.

Distribution: Protein-binding: >99%.

Metabolism: Rapidly hydrolysed to tizoxanide (active desacetyl metabolite) which partially undergoes conjugation, primarily by glucuronidation.

Excretion: Via faeces (2/3 of an oral dose); via urine (remaining dose).

Uses

Used for
- The treatment of diarrhea due to certain intestinal parasitic infections such as Cryptosporidium parvum and Giardia lamblia

How to use nitazoxanide

Always refer to your doctors instructions before taking this medication. Duration and dosage will be determined by your medical condition and its response to the medication. Make sure to take this mediciation in the prescribed amount and time period even after symptoms disappear. Discontinuing the medication before completion of treatment may cause incomplete treatment of condition. If Symptoms persist, consult your doctor

Taken by mouth; with food; usually twice a day for 3 days or as directed by your physician

Children less than 11 years of age should not take these tablets but should take nitazoxanide suspension.

Side effects

- This medication is generally well tolerated when taken as directed.
- Severe allergic reactions are rare. Get immediate medical help if you notice the following:
Rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing

Precautions

- Precautions:
  - Inform your doctor
    - Allergy to the medication or any allergies
    - Medical History of liver disease, kidney disease, weak immune system (e.g., HIV infection).
  - It is uknown if this drug passes into breast milk. Before breast-feeding, consult your physician.
  Interactions:
  
  Taking multiple drugs may affect how medications work and/or cause unwanted side effects. List down all the medications you are taking and inform your physician and pharmacist. Do not take, discontinue, or alter any dose of medications without prior approval of your physician.

Overdose & Brands

- Overdose: If overdose is suspected, contact a poison control center or emergency room immediately.
  
  Missed Dose
  
  If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and As soon as you remember, take a regular dose or if the time of the next dose is near, wait for it before taking another dose and resume your usual schedule. Do not increase the dose to compensate for the missed dose.
  
  Storage
  - Room temperature 77 degrees F (25 degrees C)
  - Brief storage between 59-86 degrees F (15-30 degrees C) is allowed
  - Do not expose to light and moisture
  - Do not store in the bathroom
  - Keep all medications away from pets and children
  Brands:
  
  Available Brands:
  
  Alinia

NITAZOXANIDE

Uses

Side effects

Precautions

Overdose & Brands

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