COMMON BRAND NAME(S): Amerge
GENERIC NAME(S): NARATRIPTAN HCL
Description: Naratriptan is a selective serotonin agonist which produces vasoconstriction of cranial arteries.
Onset: 30 min.
Pharmacokinetics:
Absorption: Bioavailability: 63% in men and 74% in women. Peak plasma concentrations after 2-3 hr (oral).
Distribution: Protein-binding: Approx 29%. Distributed into milk in rats.
Metabolism: Undergoes some hepatic metabolism by various cytochrome P450 isoenzymes.
Excretion: Primarily via urine (50% as unchanged drug, 30% as inactive metabolites). Elimination half-life: 6 hr; markedly prolonged in renal or hepatic impairment.