MYCOBACTERIUM AVIUM COMPLEX (MAC)

MYCOBACTERIUM AVIUM COMPLEX (MAC)

Mycobacterium Avium Complex (MAC) is an infection that is caused by a known group of bacteria composed of Mycobacterium intracellulare and Mycobacterium avium. This makes them also a part of the nontuberculous mycobacterium group (bacteria that do not cause tuberculosis or leprosy, but do cause pulmonary diseases that are similar to tuberculosis).

This disease is known to affect humans together, therefore being grouped as a complex. These groups of bacteria are commonly found in fresh and salt waters, in household dust and in soil. This results in a disease called Mycobacterium avium-intracellulare infection or Mycobacterium avium complex.

The bacteria is transferred via inhalation (airborne) or if swallowed (liquid state); however, this will only infect people who are immunocompromised (also known as immunodeficiency, meaning that one’s immune system is unable to combat infectious disease and cancer) or with severe lung diseases such as cystic fibrosis or chronic obstructive lung disease (COPD). Meanwhile, the infection causes COPD and lymphadenitis, which severely affects people with immunodeficiency.

TYPES

Currently, there are two major types of Mycobacterium Avium Complex (MAC) that are currently known, with each having their own strains. Listed below are the said types and their strains:

  • Mycobacterium intracellulare and its strains of ATCC 13950, CCUG 28005, CIP 104243, DSM 43223, JCM 6384, and NCTC 13025.
  • Mycobacterium avium and its strains of ATCC 25291, DSM 44156, and TMC 724.

SYMPTOMS

Most symptoms of this illness will affect the individual’s one part of the body. It will usually affect a person’s lungs, bones or intestines, which is called localized infection. However, if it spreads into the whole body, it will be then classified as a disseminated infection. People with the illness will experience the following:

  • High fever
  • Chills
  • Night sweats
  • Belly pain
  • Diarrhea
  • Weight loss
  • Fatigue
  • Swollen Glands
  • Anemia
  • Blood infections
  • Hepatitis
  • Pneumonia

DIAGNOSIS

Mycobacterium Avium Complex (MAC), several laboratory tests would be requested, aside from the physical exam. Below are the lists of tests required for diagnosis:

  • Blood test
  • Urine test
  • Sputum test (from the thick fluid from the lungs and airway)
  • Bone marrow test
  • Tissue test
  • CT scan
  • Biopsy test

Several weeks would be needed in a laboratory for the samples taken from an infected individual to have results, which will be checked for signs of MAC. That may result in the patient’s doctor to conduct additional tests if needed, like tests for anemia and liver disease.

TREATMENT

Combinations of antibiotics would be the primary medication for this illness, along with Antiretroviral Therapy (ART). The common medicines prescribed are clarithromycin, azithromycin, and ethambutol. Additional medicines such as amikacin, moxifloxacin, rifabutin, and rifampin may be issued to a patient if needed and saw fit by the doctor.

However, some may experience some side effects from some of the medications, such as:

  • Uneasiness
  • Vomiting
  • Diarrhea
  • Eye swelling with eye pain, light sensitivity, redness or blurred vision
  • Rashes and itching
  • Anemia
  • Hearing loss
  • Numbness in feet
  • Headaches

Furthermore, the medications might interfere with other medicines, such as:

  • Antifungal medications
  • Birth control pills
  • Blood-thinning drugs

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