One of the diseases affecting the brain, skin, and bones is a lysosomal storage disorder called multiple sulfatase deficiency. There are three types of multiple sulfatase deficiency, namely: neonatal, late-infantile, and juvenile. The signs and symptoms of this condition vary greatly among the three types. The most severe form, the neonatal type, has symptoms that develop promptly after birth. The most frequent type, however, is the late-infantile type. It has a clinical presentation of progressive loss of mental abilities and movement after a span of normal development. The rarest among the three types is the juvenile type. It is characterized by a slower regression of psychomotor development in mid to late childhood. In all three types, life expectancy is greatly reduced. SUMF1 gene mutations are responsible for multiple sulfatase deficiency. The disease is genetically inherited and follows an autosomal recessive pattern. Currently, there is still no cure for multiple sulfatase deficiency. Treatment is supportive and makes use of physical therapy.