METFORMIN-GLYBURIDE

Glyburide belongs to a class of drugs called sulfonylureas.  Metformin belongs to a class of drugs called biguanides. Glyburide and metformin work together to improve your blood sugar levels. Glyburide works by helping your body release more insulin. Metformin works by lowering the amount of sugar in your body.

Glyburide/metformin is used to treat type 2 diabetes in adults.

Glyburide/metformin can cause lactic acidosis. Don’t use this drug if you already have lactic acidosis. Lactic acidosis is a rare problem that happens when oxygen levels in your body drop. This leads to a buildup of lactic acid in your blood stream. It causes symptoms such as nausea, vomiting, muscle weakness, and trouble breathing. The condition can sometimes be fatal. Your risk of lactic acidosis may be higher if you have diabetes with kidney damage or heart failure.

The most common side effects that occur with glyburide/metformin include:

  • diarrhea
  • nausea
  • upset stomach
  • dizziness
  • headache
  • metallic taste in your mouth
  • gas

Mild effects may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.

Precautions

Do NOT use glyburide/ metformin if:

  • you are allergic to any ingredient in glyburide/metformin
  • you have a severe infection, low blood oxygen levels, kidney or liver problems, type 1 diabetes, or high blood ketone or acid levels (eg, diabetic ketoacidosis), or you are dehydrated
  • you have had a stroke or a recent heart attack, or you are in shock
  • you are 80 years old or older, unless lab tests show that you do not have decreased kidney function
  • you are pregnant and are within 2 weeks of the expected delivery date
  • you will be having surgery or certain lab procedures

Notify your doctor or health care provider about your past or present medical conditions. This may interact with your medication or worst, bring complications.

 

Interactions

Glyburide/metformin can interact with other medications, herbs, or vitamins you might be taking. That’s why your doctor should manage all of your medications carefully. If you’re curious about how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

If you think that you’ve taken too much glyburide/metformin, go to the emergency room right away or call your local poison control center.

 

Available brands:

  • Bemefor
  • Euglo Plus
  • Glibenclamide + Metformin
  • Glucovance
  • Rapartam

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