Malignant hyperthermia (MH) is a life-threatening, hypermetabolic clinical condition affecting the skeletal muscle. It is caused by volatile inhalation of anesthetic agents and muscle relaxant succinylcholine in susceptible individuals mainly, although other medications have also been involved as potential triggers. MH is not an allergy but is an acquired condition found in humans and swine alike.
Malignant hyperthermia (MH) is a primarily acquired skeletal muscle disease predisposing individuals to a deadly adverse reaction (fulminant MH event) to potent volatile anesthetics (halothane, isoflurane, sevoflurane, desflurane, etc.) and succinylcholine.
One of many genetic mutations is causing muscle abnormality, which can lead to malignant hyperthermia. Around half of all cases are caused by the most frequent mutation. An individual with this mutation has one in two opportunities to pass the gene on to either of his or her offspring.
Family members may have different levels of medication sensitivity, which causes the issue. Reactions are, in some situations, mild. Until having an identifiable response, a person may be exposed to high-risk drugs many times.
This disorder often happens in people with muscular dystrophy, too. It also exists in many genetic mutation-associated muscle diseases.
