Description: Mafenide is a topical antibacterial with a wide spectrum of activity.

  • Treatment and prevention of wound infections in patients with severe burns
  • Belongs to a class of drugs known as sulfa antibiotics

How to use mafenide topical

  • Handwashing is required before and after application of this medicine. This medication is for skin use only. After cleaning the affected area, apply this medication to the wound while wearing a clean pair of medical gloves (e.g., latex, vinyl), usually once or twice a day or as directed by your physician. The layer of cream applied should be about one-sixteenth of an inch (1 to 2 millimeters) thick. And wound should be constantly be covered with the medication. Covering the wound with gauze or bandages is not required. If some of the cream rubs off the wound, re-apply it right away.
  • Bathing at least once a day is recommended to help remove dead skin and allow wound healing. Medication must be re-applied after bathing.

Minor side effects (if these symptoms persist or worsen, inform your doctor)

  • Pain, burning, or redness may occur

Serious side effects (inform your doctor immediately)

  • Blisters, bleeding, fast breathing, nausea, vomiting, diarrhea, headache, change in alertness, shaking (tremors), seizures, weakness, dark urine, stomach/abdominal pain, arm/leg/back pain, fast heartbeat

Severe allergic reactions are rare. Get immediate medical help if you notice the following:

  • Rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing


  • Inform your doctor
    • Allergy to the medication or any allergies
    • Medical History of lung problems (e.g., asthma), kidney disease, metabolism problems (e.g., glucose-6-phosphate dehydrogenase deficiency-G6PD), blood disorders.
  • Should only be used when there is a clear need during pregnancy as it may harm an unborn baby. If you are planning to be pregnant or think you may be pregnant, discuss the risks and benefits of use with your doctor.
  • It is unknown if this drug passes into breast milk. Before breast-feeding, consult your physician.



Taking multiple drugs may affect how medications work and/or cause unwanted side effects. List down all the medications you are taking and inform your physician and pharmacist. Do not take, discontinue, or alter any dose of medications without prior approval of your physician.

  • If overdose is suspected, contact a poison control center or emergency room immediately This medicine may be harmful if swallowed. Symptoms following swallowing may include diarrhea.

Missed Dose: If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and as soon as you remember, apply a regular dose or if the time of the next dose is near, wait for it before applying another dose and resume your usual schedule. Do not increase the dose to compensate for the missed dose.


  • Room temperature below 40 degrees C
  • Do not expose to light and moisture
  • Do not store in the bathroom
  • Keep all medications away from pets and children

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