Description: Lovastatin reduces cholesterol by competitively inhibiting HMG-CoA reductase, the rate-limiting step in cholesterol biosynthesis.


Absorption: 30% absorbed from the GI tract. Time to peak plasma concentration: W/in 2-4 hr.

Distribution: <5% reach the circulation. Plasma protein binding: >95%.

Metabolism: Extensively hepatic via hydrolysis; converted to active β-hydroxyacid form.

Excretion: Via faeces (approx 85%); via urine (approx 10%). Elimination half-life: 1-2 hr.

Lovastatin is a “statin” that lowers “bad” cholesterol and fats (such as LDL, triglycerides) and raises “good” cholesterol (HDL) in the blood. It works by reducing the amount of cholesterol made by the liver. It is used along with a proper diet to increase its effectiveness.

How to use lovastatin

Take this medication by mouth as directed by your doctor, usually once daily with your evening meal. Some patients may be directed to take this medication twice daily.

Dosage is based on your medical condition, response to treatment, age, and other medications you may be taking. Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Avoid eating grapefruit or drinking grapefruit juice while using this medication unless your doctor instructs you otherwise. Grapefruit can increase the amount of this medication in your bloodstream. Consult your doctor or pharmacist for more details.

If you also take certain other drugs to lower your cholesterol (bile acid-binding resins such as cholestyramine or colestipol), take lovastatin at least 1 hour before or at least 4 hours after taking these medications. These products can react with lovastatin, preventing its full absorption.

Take this medication regularly in order to get the most benefit from it. Remember to take it at the same time(s) each day. It is important to continue taking this medication even if you feel well. Most people with high cholesterol or triglycerides do not feel sick.

It is very important to continue to follow your doctor’s advice about diet and exercise. It may take up to 4 weeks before you get the full benefit of this drug.

Talk to your doctor if rare effects occur such as mild memory problems or confusion.

Rarely, statins may cause or worsen diabetes.

This drug may infrequently cause muscle problems (which can rarely lead to very serious conditions called rhabdomyolysis and autoimmune myopathy).

This medication may rarely cause liver problems.

A very serious allergic reaction to this drug is rare.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

  • Allergic reaction to this medication
  • Patients with medical history of liver disease, kidney disease, o alcohol use
  • Tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products) before having surgery
  • Limit alcoholic beverages
  • Older adults may be more sensitive to muscle problems
  • This medication must not be used during pregnancy
  • Consult your doctor before breast-feeding

Consult your doctor regarding the precautions mentioned above.



“Blood thinners” (such as warfarin) and gemfibrozil may interact with this drug include:.

Other medications can affect the removal of lovastatin from your body, which may affect how lovastatin works. Examples are:

  • certain azole antifungals (such as itraconazole, ketoconazole)
  • cobicistat
  • colchicine
  • cyclosporine
  • delavirdine
  • telithromycin
  • macrolide antibiotics (such as clarithromycin, erythromycin)
  • nefazodone
  • HIV protease inhibitors (such as lopinavir, ritonavir)
  • hepatitis C virus protease inhibitors (such as boceprevir, telaprevir)

Taking lovastatin and red yeast rice products together can increase your risk of serious muscle and liver problems.

If overdose is suspected, contact a poison control center or emergency room immediately.


Do not share this medication with others.

Laboratory and/or medical tests (such as blood cholesterol/triglyceride levels) should be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details.

Missed Dose

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.


Store at room temperature away from light and moisture. Storage temperature ranges differ according to different manufacturers, so consult your pharmacist for more information. Do not store in the bathroom. Keep all medicines away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.



Also marketed as:


International Apex Lovastatin [ Duopharma (M) Sdn Bhd ]

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