COMMON BRAND NAME(S): Ceenu, Gleostine
GENERIC NAME(S): LOMUSTINE
Description: Lomustine inhibits the synthesis of DNA and RNA via alkylation although carbamoylation and modification of cellular proteins may also be involved.
Absorption: Rapidly absorbed from the GI tract (oral); also absorbed after topical application. Peak plasma concentrations of metabolites after 1-6 hr (oral).
Distribution: Widely distributed; drug and metabolites cross the blood-brain barrier; active metabolites appear in CSF within 30 min (oral); metabolites present in milk.
Metabolism: Hepatic via hydroxylation; enterohepatically recycled.
Excretion: Via urine (approx 50%); via faeces (<5%); via expired air (<10%).