Lisdexamfetamine is an amphetamine that works by affecting certain chemicals in the brain that may help improve attention span and behavior.

This medication is used as part of a treatment program to control symptoms of attention deficit hyperactivity disorder (ADHD; more difficulty focusing, controlling actions, and remaining still or quiet than other people who are the same age) in adults and children.

Lisdexamfetamine can also used to treat binge eating disorder (an eating disorder characterized by periods of uncontrolled overeating).

Lisdexamfetamine has a high risk for abuse. It may be habit-forming if used for a long period of time. Use lisdexamfetamine only as prescribed. Do not share it with others. Abuse of lisdexamfetamine may cause serious heart problems, blood vessel problems, or sudden death.

Common side effects of this drug may include:

  • Difficulty Falling Asleep or Staying Asleep
  • Sleepiness
  • Dizziness
  • Feeling Anxious
  • Jitters
  • Headache
  • Dry Mouth
  • Stomach Pain
  • Constipation
  • Diarrhea
  • Nausea
  • Vomiting
  • Loss of Appetite
  • Weight Loss
  • Sweating

Tell your doctor if the following symptoms persist or worsen.

Call your doctor immediately if you experienced severe side effects such as:

  • Fast or Pounding Heartbeat
  • Uncontrollable Shaking of a Part of the Body
  • Chest Pain
  • Shortness of Breath
  • Fainting
  • Slow or Difficult Speech
  • Weakness or Numbness of an Arm or Leg
  • Seizures
  • Hallucinating (Seeing Things or Hearing Voices that do not Exist)
  • Believing Things that are Not True
  • Feeling Unusually Suspicious Of Others
  • Aggression
  • Irritability
  • Mood Swings
  • Frenzied, Abnormally Excited Mood
  • Motor Tics or Verbal Tics
  • Hives
  • Rash
  • Swelling of the Eyes, Face, Tongue, Lips, or Mouth
  • Blurred Vision or Other Vision Problems
  • Paleness or Blue Color of Fingers or Toes
  • Numbness, Pain, or Sensitivity to Temperature in the Fingers or Toes
  • Unexplained Wounds Appearing on Fingers or Toes


Before taking this medication, tell your doctor or pharmacist your:

  • Allergies to any component of this drug or other sympathomimetic drugs (such as Amphetamine or Dextroamphetamine); or if you have any other allergies.
  • Medical history, especially of:
    • Blood Circulation Problems (such as Raynaud’s Disease)
    • Certain Mental/Mood Conditions (such as Severe Agitation, Psychosis)
    • Personal/Family History of Mental/Mood Disorders (such as Bipolar Disorder, Depression, Psychotic Disorder, Suicidal Thoughts)
    • Heart Problems (Including Irregular Heartbeat, Coronary Artery Disease, Previous Heart Attack, Heart Failure, Cardiomyopathy, Problems With Heart Structure such as Valve Problems)
    • Family History of Heart Problems (such as Sudden Death, Irregular Heartbeat), History Of Stroke, High Blood Pressure
    • Overactive Thyroid (Hyperthyroidism)
    • A Certain Eye Problem (Glaucoma)
    • Seizures
    • Kidney Disease
    • Personal/Family History of Regular Use/Abuse of Drugs/Alcohol
  • Personal/Family History of Uncontrolled Muscle Movements (such as Tourette’s Syndrome)



Some medicines may interact with lisdexamfetamine. Tell your health care provider if you are taking any other medicines including prescription and nonprescription, especially any of the following:

  • MAOIs (eg, Phenelzine)

-Side effects, such as severe high blood pressure, fever, headache, and irregular heartbeat, may occur

  • Alkalinizing agents (eg, Acetazolamide, Sodium bicarbonate)

They may increase the risk of Lisdexamfetamine’s side effects

  • Ascorbic acid (vitamin C) or urinary acidifiers (eg, Methenamine, Ammonium Chloride) -They may decrease Lisdexamfetamine’s effectiveness

Call emergency hotline if someone has overdosed and has serious symptoms such as passing out or trouble breathing.

Symptoms of overdose may include:

  • Severe Mental/Mood Changes (such as Confusion, Hallucinations)
  • Seizures
  • Irregular Heartbeat
  • Severe Restlessness
  • Fast Breathing

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