LIDOCAINE + PRILOCAINE - Uses, Warnings, Side effects, Precautions


Lidocaine and Prilocaine are local anaesthetics combined to stabilize the neuronal membranes and inhibit the sodium ion channels needed for the activation and movement of neuronal impulses.

Use this medication precisely as recommended by your physician. Follow the prescription of your doctor carefully.

The medication dose given by your physician is based on your health conditions, other medications or food supplements taken, and your reaction to the treatment. To diminish risks for adverse effects, do not increase your dosage, thus take it regularly, or take it as instructed by your physician. Adverse events may still happen even at usual prescription dosages.

If your physician requests you to use this drug consistently, take it regularly to get the most benefits from it. To make you remember it better, take it at a fixed time every day.

Your doctor may need to modify your dosages to ease your symptoms or if you develop adverse reactions.

Lidocaine + Prilocaine is used in the following conditions:

  • Topical anaesthesia
  • Primary premature ejaculation
  • Local anesthesia

This medicine may be recommended for different uses. Approach your physician or pharmacist for more information.  

Do not use Lidocaine + Prilocaine in people with the following conditions:

  • Congenital, idiopathic or acquired methemoglobinemia
  • Newborn infants or infants less than 12 months
  • Preterm newborn infants with gestational age
  • Application to broken or inflamed skin
  • Open wounds
  • Near eyes

Lidocaine + Prilocainemay have the following side effects:

  • Allergic and anaphylactic reactions
  • Eye irritation
  • Numbness of oral mucosa
  • Erectile dysfunction
  • Male genital hypoesthesia
  • Nausea
  • Taste perversion
  • Throat irritation
  • Fatigue
  • Flu-like disorder
  • Pyrexia
  • Local alteration in temperature sensations
  • Application site reactions such as pruritus, erythema, burning or stinging sensation
  • Warmth
  • Pallor
  • Rarely purpuric or petechial lesions
  • Local pain
  • Edema
  • Numbness
  • Soreness 
  • Irritation
  • Ulceration
  • Abscess
  • Vesicles
  • Myalgia
  • Arthralgia
  • Headache
  • Dizziness
  • Genital burning sensation
  • Hypoaesthesia
  • Vulvovaginal burning sensation in female partners
  • Respiratory tract infection
  • Rhinitis
  • Urticaria
  • Rarely, hyperpigmentation
  • Methemoglobinemia

Keep in mind that your physician has recommended this drug since he or she has known that the advantage to you is more significant than the risk of adverse reactions. Many individuals utilizing this medicine don’t have serious side effects.  

A severe allergy to this medication is uncommon. In any case, seek emergency medical help if you see any manifestations of a serious allergic response, including a rash, tingling or swelling particularly of the face or tongue or throat, dizziness or difficulty in breathing.

This is not a complete list of side effects. If you see other effects not recorded above, contact your physician or pharmacist.


Take extra caution in patients with the following medical conditions:

  • Patients with history of drug sensitivities
  • G6PD deficiency
  • Anemia
  • Severe impairment of impulse initiation
  • Heart conduction 
  • Cardiac or pulmonary compromise
  • Concurrent exposure to oxidising agents or their metabolites
  • Atomic dermatitis
  • Patients who are in remission from porphyria
  • Asymptomatic carriers of mutated genes responsible for porphyria development
  • Acutely ill or debilitated patients
  • Ulcerative lesions or during acute cavity infections
  • Children
  • Elderly
  • Pregnancy
  • Lactation

Prior in taking this medicine, tell your physician or pharmacist if you have allergies  or other hypersensitivity reactions with the drug. This drug may contain inert ingredients which can cause unfavorable side effects or different issues. Talk with your pharmacist for more information.


Lidocaine + Prilocaine may interact with the following medicines:

    • Dental inj anaesthesia
    • Class I antiarrhythmics
    •  Class III antiarrhythmics
  • Potentially fatal: Local anaesthetics, Nitrates/ Nitrates, Antineoplastic agents, Cyclophosphamide, Antibacterials, Antimalarial, Anticonvulsants

Inform your physician about the drugs you take including over-the-counter medications, prescribed drugs, supplements and vitamins.

This is not a complete list of drug interactions. Approach your physician or pharmacist for more details.

The effects of certain medications can change if you consume different medications or herbal products simultaneously. This can build your risk for side effects or may cause your drugs not to work effectively. These interactions are possible, yet don’t generally happen. Your physician or pharmacist can prevent or oversee interactions by changing how you utilize your prescriptions or by close checking.

While utilizing this drug, don’t start, stop, or change the dose of other medicines you are using without your physician’s advice.

If an overdose is suspected, call your health care provider immediately.

Available brands:

  • Emla
  • Emlocaine
  • Combikane
  • Emlopril
  • Metacain DS

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