LEVOFLOXACIN - Watsons Health



Levofloxacin is a drug that is also known as an antibiotic. It exerts antibacterial action by inhibiting bacterial topoisomerase IV and DNA gyrase, the enzymes required for DNA replication, transcription repair and recombination. It has effects against gram-positive and gram-negative microorganisms.

Levofloxacin is used in the treatment of infections such as pneumonia and urinary tract infection.

Do not take Levofloxacin if with hypersensitivity to levofloxacin or other quinolones.

Levofloxacin may give rise to the following side effects:

  • Gastrointestinal effects (example nausea, diarrhea, constipation)
  • Headache
  • Insomnia
  • Dizziness
  • Tendinitis
  • Tendon rupture
  • Photosensitivity and phototoxicity reactions
  • Peripheral neuropathy (irreversible)
  • Hypoglycemia or hyperglycemia
  • Prolonged QT interval leading to ventricular arrhythmias, including torsades de pointes
  • Musculoskeletal disorders (example arthralgia, arthritis, gait abnormality, tendinopathy)
  • Fever
  • Transient decrease in vision
  • Ocular burning
  • Pain
  • Dryness
  • Itching or discomfort
  • Foreign body sensation
  • Pharyngitis
  • Photophobia
  • Uveitis
  • Allergic reactions
  • Lid edema
  • Hypersensitivity and/or anaphylactic reactions
  • Severe hepatotoxicity including hepatitis
  • Clostridium difficile-associated diarrhea and colitis


Take special precautions in people with the following conditions:

  • Patient with known or suspected central nervous system disorders (example, severe cerebral arteriosclerosis, epilepsy)
  • Other risk factors that predispose to seizures or lower the seizure threshold
  • History of psychiatric disease and tendon disorder
  • History of prolonged QT interval
  • Uncorrected electrolyte disorders (example hypokalemia)
  • Latent or actual defects in G6PD
  • Diabetes mellitus
  • Kidney
  • Heart or lung transplant recipients
  • May exacerbate myasthenia gravis
  • Renal impairment
  • Children
  • Pregnancy
  • Lactation



Levofloxacin may interact with the following medicines:

  • Class IA (example quinidine, procainamide) or class III (amiodarone, sotalol)
  • Antiarrhythmics
  • Fluoxetine or imipramine
  • Sucralfate
  • Didanosine
  • Antacids containing Magnesium or Aluminum
  • Dietary supplements containing Zinc, Calcium, Magnesium or Ferrous
  • Antidiabetic agents (example insulin, glibenclamide)
  • Corticosteroids
  • NSAIDs
  • Warfarin

Symptoms of Levofloxacin overdose include the following:

  • Confusion
  • Dizziness
  • Impairment of consciousness
  • Convulsive seizures
  • Increases in QT interval
  • Nausea
  • Mucosal erosions

Seek medical help immediately.

Available Brands:

Axa-Levo, Ceflox 500, Celevo, Floxel, Glevo, Lefocin, Levocin, Levoflox, Levofloxin, Levomax, Ami-Levo, Axoflon, Flevoxcin, Floxiprime, Hermeris, Ilevox, Lefloxin, Levflox, Levobact


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