LEUPRORELIN - Watsons Health


Leuprorelin is also known as leuprolide is given by injection into a muscle or under the skin.

It is used to treat prostate cancer, breast cancer, endometriosis, uterine fibroids, and early puberty.

Initially, leuprolide use increases in serum levels of testosterone. Transient worsening of symptoms, or the occurrence of additional signs and symptoms of prostate cancer, may occasionally develop during the first few weeks of the treatment. Safety of this medication for pregnant women has not been established clinically.

Side effects may include: general pain, headache, asthaenia, nausea, vomiting, oedema, weight changes, acne, hirsutism, dizziness, insomnia, sleep disturbance, paraesthesias, skin reactions, effects of hypoestrogenism such as hot flashes, joint disorder, myalgia, decreased libido, depression, emotional lability, nervousness, breast tenderness, and vaginitis.


May cause transient elevation of testosterone levels during the first 1-2 wk, which may lead to worsening or onset of new symptoms (e.g. bone pain, neuropathy, and haematuria) in prostate cancer patients. Ureteral obstruction and spinal cord compression have been reported; closely monitor patients with urinary obstruction and/or metastatic vertebral lesion. Leuprorelin is associated with increased risk of diabetes and certain CV diseases (heart attack, sudden cardiac death, stroke) when used in men for treatment of prostate cancer. For prostate cancer, monitor response by testosterone and prostate-specific antigen (PSA) levels. For precocious puberty in children, monitor response by GnRH stimulation test sex steroid levels 1-2 month after treatment initiation. Leuprorelin usually inhibits ovulation and stops menstruation in women, but does not incur contraception, non-hormonal contraception should be used as pregnancy is contraindicated.



It may have adverse reactions associated with hypoestrogenism and loss in bone density. It may also affect pregnancy, lactation; hypersensitivity to GnRH, GnRH agonist analogs or product excipients; undiagnosed abnormal vaginal bleeding.

If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call emergency hotline.


Available Brands

  • Endrolin
  • Luprolex/Luprolex Depot
  • Luphere Depot

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