LANTHANUM CARBONATE

Lanthanum carbonate is a phosphate binder which inhibits the absorption of dietary phosphate from the intestines. It disintegrates in the gastrointestinal tract to lanthanum ions (La3+) that binds phosphate to make insoluble and not absorbable lanthanum phosphate complexes, causing a decrease in serum phosphate and calcium levels.

Uses

Lanthanum carbonate is used to treat hyperphosphatemia in patients with chronic renal failure.

Warnings

Avoid using Lanthanum carbonate in the following conditions:

Bowel obstruction
Ileus
Faecal impaction
Hyperphosphataemia

Side Effects

Lanthanum carbonate may have the following side effects:

Significant: GI obstruction, ileus, subileus, GI perforation, faecal impaction.
Nervous: Headache, dizziness, vertigo, asthenia, fatigue, malaise.
GI: Nausea, vomiting, diarrhoea, abdominal pain, taste alteration, gastroenteritis, constipation, dyspepsia, flatulence, dry mouth, eructation, IBS, anorexia.
Endocrine: Hyperglycaemia, hyperparathyroidism.
Haematologic: Eosinophilia.
Musculoskeletal: Bone deposition, arthralgia, myalgia, and osteoporosis.
Dermatologic: Alopecia, sweating.
Others: Hypocalcaemia, hyperphosphataemia, hypophosphataemia, hypercalcaemia.

Precautions

Precautions

Take precautions in people with the following conditions:

Altered gastrointestinal anatomy (e.g. diverticular disease, peritonitis, history of gastrointestinal surgery, gastrointestinal cancer, gastrointestinal ulceration)
Hypomotility disorders (e.g. constipation, diabetic gastroparesis)
Active peptic ulcer
Crohn’s disease
Ulcerative colitis
Hepatic impairment
Pregnancy and lactation

Interactions

Lanthanum carbonate may interact with the following medicines:

Quinolones
Tetracycline
Levothyroxine
Chloroquine
Ketoconazole
ACE inhibitor
Ampicillin
Halofantrine

Overdose & Brands

Symptoms of overdose include headache, nausea and vomiting.

Seek medical treatment immediately.

Available Brand:

Fosrenol