LANTHANUM CARBONATE - Watsons Health

LANTHANUM CARBONATE

Lanthanum carbonate is a phosphate binder which inhibits the absorption of dietary phosphate from the intestines. It disintegrates in the gastrointestinal tract to lanthanum ions (La3+) that binds phosphate to make insoluble and not absorbable lanthanum phosphate complexes, causing a decrease in serum phosphate and calcium levels.

Lanthanum carbonate is used to treat hyperphosphatemia in patients with chronic renal failure.

Avoid using Lanthanum carbonate in the following conditions:

  • Bowel obstruction
  • Ileus
  • Faecal impaction
  • Hyperphosphataemia

Lanthanum carbonate may have the following side effects:

Significant: GI obstruction, ileus, subileus, GI perforation, faecal impaction.
Nervous: Headache, dizziness, vertigo, asthenia, fatigue, malaise.
GI: Nausea, vomiting, diarrhoea, abdominal pain, taste alteration, gastroenteritis, constipation, dyspepsia, flatulence, dry mouth, eructation, IBS, anorexia.
Endocrine: Hyperglycaemia, hyperparathyroidism.
Haematologic: Eosinophilia.
Musculoskeletal: Bone deposition, arthralgia, myalgia, and osteoporosis.
Dermatologic: Alopecia, sweating.
Others: Hypocalcaemia, hyperphosphataemia, hypophosphataemia, hypercalcaemia.

Precautions

Take precautions in people with the following conditions:

  • Altered gastrointestinal anatomy (e.g. diverticular disease, peritonitis, history of gastrointestinal surgery, gastrointestinal cancer, gastrointestinal ulceration)
  • Hypomotility disorders (e.g. constipation, diabetic gastroparesis)
  • Active peptic ulcer
  • Crohn’s disease
  • Ulcerative colitis
  • Hepatic impairment
  • Pregnancy and lactation

 

Interactions

Lanthanum carbonate may interact with the following medicines:

  • Quinolones
  • Tetracycline
  • Levothyroxine
  • Chloroquine
  • Ketoconazole
  • ACE inhibitor
  • Ampicillin
  • Halofantrine

Symptoms of overdose include headache, nausea and vomiting.

Seek medical treatment immediately.

 

Available Brand:

  • Fosrenol

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