Description: Isoxsuprine is an α-receptor antagonist with β-receptor agonist action that causes peripheral and cerebral vasodilatation. It also causes cardiac and uterine relaxation.

This medication decreases symptoms such as cold hands and feet, numbness, tingling, and decreased memory or judgment because it works by widening blood vessels to help increase blood flow (improve circulation) to certain parts of the body (e.g., hands/feet, brain). It is used along with other treatment for certain blood vessel diseases (e.g., arteriosclerosis obliterans, Raynaud’s disease, Buerger’s disease, cerebrovascular insufficiency).

How to use isoxsuprine

This medication is taken by mouth with or without food, usually 3 to 4 times daily or as directed by your doctor. Dosage is based on your medical condition and response to treatment.

Use this medication regularly to get the most benefit from it. To help you remember, take it at the same times each day.

Tell your doctor if your condition persists or worsens.

not available

Tell your doctor or pharmacist promptly if any of these effects persist or worsen:

  • Dizziness
  • Flushing
  • stomach upset
  • nausea
  • shaking
  • nervousness

Tell your doctor immediately if fast/pounding heartbeat or weakness occur.

Seek immediate medical attention if chest pain occurs.

A very serious allergic reaction to this drug is rare.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.


  • Allergic reaction to this medication
  • Patients with current abnormal bleeding or recent childbirth
  • Patients with medical history of:
    • bleeding disorders
    • glaucoma
    • heart disease (including recent heart attack)
  • This drug may make you dizzy
  • This medication should be used only when clearly needed during pregnancy
  • Consult your doctor before breast-feeding

Consult your doctor regarding the precautions mentioned above.


Tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use before using this medication.

Check the labels on all your medicines (e.g., cough-and-cold products, diet aids) because they may contain ingredients that could increase your heart rate or affect your blood pressure.

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.


If overdose is suspected, contact a poison control center or emergency room immediately. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.


Do not share this medication with others.

Missed Dose

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.


Store at room temperature between 59-86 degrees F (15-30 degrees C) away from light and moisture. Do not store in the bathroom. Keep all medicines away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.



Available Brands:

Drugmaker’s Isoxsuprine Hydrochloride [ Drugmaker’s Lab ] Suprinex [ Saga Lab ]

Also marketed as

Duvacare [ JM Tolmann ] Duvadilan [ Abbott ]
Duvagen [ InnoGen Pharmaceuticals ] Duvaprine [ Ultramed ]
Isoxilan [ BioFemme ] Uteprine [ Lloyd ]

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