ISOSORBIDE DINITRATE - Watsons Health

ISOSORBIDE DINITRATE

Isosorbide dinitrate is a nitrate. It works by relaxing the blood vessels in the body, allowing them to widen. This lets more blood flow through the blood vessels, which reduces the work the heart has to do to pump blood. This reduces the oxygen needs of the heart and decreases chest pain.

Isosorbide dinitrate is a medication used to treat and prevent chest pain due to insufficient blood flow to the heart. It is also used for the treatment of heart failure.

Do NOT use isosorbide dinitrate if:

  • you are allergic to any ingredient in isosorbide dinitrate
  • you are taking avanafil, riociguat, sildenafil, tadalafil, or vardenafil

Do not give to patients with raised intracranial pressure, hypotension, hypovolemia, mitral valve prolapse, arterial hypoxemia, glaucoma, hypothyroidism, malnutrition, as well as to the elderly and pregnan and lactating women.

Headache, dizziness, lightheadedness, nausea, and flushing may occur as your body adjusts to the medication. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Headache is often a sign that this medication is working. Your doctor may recommend treating headaches with an over-the-counter pain reliever (such as acetaminophen, aspirin). If the headaches continue or become severe, tell your doctor promptly.

To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if any of these unlikely but serious side effects occur: fainting, fast/irregular/pounding heartbeat.

Precautions

Before taking this medication, tell your doctor or pharmacist if you are allergic to it; or to similar drugs (such as isosorbide mononitrate, nitroglycerin); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: recent head injury, frequent stomach cramping/watery stools/severe diarrhea (GI hypermotility), lack of proper absorption of nutrients (malabsorption).

 

Interactions

Some products that may interact with this drug include: drugs to treat erectile dysfunction-ED or pulmonary hypertension (such as sildenafil, tadalafil), certain drugs to treat migraine headaches (ergot alkaloids such as ergotamine), riociguat.

Check the labels on all your medicines (such as cough-and-cold products, diet aids, or NSAIDs such as ibuprofen, naproxen) because they may contain ingredients that could worsen symptoms of heart failure. Ask your pharmacist for more details.

Isosorbide dinitrate is very similar to isosorbide mononitrate. Do not use medications containing isosorbide mononitrate while using isosorbide dinitrate.

This medication may interfere with certain laboratory tests (including blood cholesterol levels), possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug.

If overdose is suspected, bring the victim to the hospital immediately.

 

Available brands:

  • Isoket (MSD)
  • Isordil (Pfizer)

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