ILOPROST

COMMON BRAND NAME(S): Ventavis

GENERIC NAME(S): ILOPROST TROMETHAMINE

 

Description: Iloprost is a synthetic analogue of prostaglandin epoprostenol that is an agent for vasodilation and platelet-aggregation inhibitor.

Pharmacokinetics:

Distribution: Apparent steady-state volume of distribution following IV infusion: 0.7-0.8 L/kg in healthy subjects. Protein-binding: 60%, mainly to albumin.

Metabolism: Metabolised primarily to tetranor-iloprost via ß-oxidation of the carboxyl side chain.

Excretion: 80% of the metabolites excreted in the urine, 20% in the bile.

This medication treats pulmonary arterial hypertension by relaxing and widening the blood vessels (arteries) in the lungs and other parts of the body so that blood can flow more easily. It helps to increase your ability to exercise and improves symptoms such as shortness of breath and tiredness.

 

How to use iloprost inhalation

Read the Patient Information Leaflet available from your pharmacist. This medication comes in a glass bottle (ampule). Follow the manufacturer’s instructions on how to open the ampule and how to prepare each dose. This product is used with a special breathing device (nebulizer). Ask your doctor, pharmacist or respiratory therapist how to inhale this medication properly with this equipment. Make sure you understand how to properly clean the nebulizer to prevent infections.

 

Before using, check this product visually for particles or discoloration. If either is present, do not use the liquid. Do not mix with other medications in the nebulizer.

 

Inhale this medication by mouth as directed by your doctor, usually 6 to 9 times daily, at least 2 hours apart. Do not drink the solution. Do not get this medication on the skin or in your eyes. If this happens, rinse the area with water. The dosage is based on your medical condition and response to treatment.

 

Use this medication regularly to get the most benefit from it. To help you remember, use it at the same times each day.

 

To avoid not being able to use your medication, be sure to have access to a back-up nebulizer in case your regular device stops working properly.

 

Tell your doctor if your condition does not improve or if it worsens.

Tell your doctor or pharmacist promptly if any of these effects persist or worsen:

 

  • Nausea
  • Vomiting
  • Diarrhea
  • Headache
  • Dizziness
  • jaw pain
  • flushing
  • trouble sleeping
  • muscle spasms of the jaw

 

 

 

Tell your doctor immediately if any of these unlikely but serious side effects occur:

 

  • Wheezing
  • sudden weight gain
  • worsening breathing
  • chest pain
  • fainting

 

 

A very serious allergic reaction to this drug is rare.

 

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Precautions

 

  • Allergic reaction to this medication
  • Patients with medical history of:
    • low blood pressure
    • liver problems
    • kidney problems
    • bleeding problems
    • other breathing problems (such as asthma)
  • This drug may make you dizzy
  • This medication should be used only when clearly needed during pregnancy
  • Consult your doctor before breast-feeding

Consult your doctor regarding the precautions mentioned above.

 

Interactions

 

Iloprost may increase your risk of bleeding if you take “blood thinners.” Tell your doctor or pharmacist immediately if you develop symptoms such as easy or unusual bleeding/bruising, severe dizziness, or fainting.

 

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.

Overdose

 

If overdose is suspected, contact a poison control center or emergency room immediately. Symptoms of overdose may include: severe dizziness, fainting.

 

Notes

Do not share this medication with others.

 

Laboratory and/or medical tests (such as blood pressure, liver function tests) may be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details.

 

Missed Dose

If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

 

Storage

Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

 

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

 

Brands


There are no brands containing this molecule.

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