Icterus (chronic familial) affects the membrane on the surface of your RBC. Instead of flattened discs with inward bends, your red blood cells now resemble spheres. Spherical cells are less elastic than regular RBCs.
The spleen initiates the immune system’s reaction to infections in a healthy body. Moreover, the spleen is in charge of removing pathogens and damaged cells from circulation. Hence, spherocytosis makes it difficult for RBC to flow through your spleen because of its shape and stiffness.
Red blood cells can be broken down more quickly by the spleen because of their irregular form. This kind of anemia is known as hemolytic anemia. Additionally, a healthy RBC can survive for up to 120 days, whereas those who have icterus (chronic familial) may only survive for ten to thirty days.