Iclusig is a prescription medication used to treat the symptoms of Acute Lymphoblastic Leukemia and Chronic Myeloid Leukemia. It may be used alone or in combination with other drugs.

Additionally, Iclusig belongs to the Antineoplastics, Tyrosine Kinase Inhibitor class of medicines, which inhibits the development of specific cancer cells. Iclusig is frequently used after other comparable drugs have failed.

Use this medication precisely as recommended by your physician. Follow the prescription of your doctor carefully. 

The medication dose your physician has given is based on your condition, other medications or food supplements you may take, and your reaction to treatment. To diminish your risks for adverse effects, don’t increase your dosage. Take it regularly, or take it as instructed by your physician. Adverse events may still happen even at usual prescription dosages. 

If your physician requests you to use this drug consistently, use it regularly to get the most benefits from it. To make you remember it better, take it at a fixed time every day. 

Your doctor may need to modify your dosages to ease your symptoms or if you develop adverse reactions. 

If you have any inquiries with regards to information, ask your physician or pharmacist.

Iclusig is used in the following conditions:

  • Intolerance to nilotinib or dasatinib
  • Philadelphia chromosome positive acute lymphoblastic leukemia
  • Adults with chronic, accelerated, or blast phase of chronic myeloid leukemia resistant to dasatinib or nilotinib
  • T315I mutation
  • Chronic myeloid leukemia

This medicine may be recommended for different uses. Approach your physician or pharmacist for more information.  

Do not use Iclusig in people with the following conditions:

  • Hypersensitivity

May have the following side effects:

  • Anemia
  • Decreased appetite
  • Headache
  • HTN
  • Cough
  • Diarrhea
  • Constipation
  • Increased lipase
  • Rash
  • Pruritus
  • Arthralgia
  • Extreme pain
  • Muscle spasms
  • Asthenia
  • Pyrexia
  • Upper respiratory tract infection
  • Decreased neutrophil/platelet count
  • Insomnia
  • Dizziness
  • Dyspnea
  • Abdominal pain
  • Vomiting
  • Nausea
  • Increased AST/ALT
  • Dry skin
  • Bone pain
  • Myalgia
  • Back pain
  • Fatigue
  • Peripheral edema

Keep in mind that your physician has recommended this drug since he or she has known that the advantage to you is more noteworthy than the risk of adverse reactions. Many individuals utilizing this medicine don’t have serious side effects.  

A serious allergy to this medication is uncommon. In any case, seek emergency medical help if you see any manifestations of a serious allergic response, including a rash, tingling or swelling particularly of the face or tongue or throat, dizziness or difficulty in breathing. 

This is not a complete list of side effects. If you see other effects not recorded above, contact your physician or pharmacist.

Take extra caution in patients with the following medical conditions:

  • Fatal MI
  • Retinal arteries occlusions that have been associated with persistent vision loss or impairment
  • Severe peripheral vascular disease
  • Aneurysm
  • Pancreatitis
  • Hemorrhage
  • Posterior reversible encephalopathy syndrome
  • QT prolongation
  • Glucose-galactose malabsorption
  • Pregnancy
  • Children
  • Myelosuppression
  • Stroke
  • Stenosis of large arterial vessels of the brain
  • Renal artery stenosis
  • Artery dissections
  • Haptoxicity
  • Hepatitis B reactivation
  • Risk of bleeding with anti-clotting agents
  • Galactose intolerance
  • Hepatic or renal impairment
  • Lactation

Prior to taking this medicine, tell your physician or pharmacist if you are allergic to it, or if you have some other hypersensitivities. This drug may contain inert ingredients which can cause unfavorable side effects or different issues. Talk with your pharmacist for more information.


Iclusig may interact with the following medicines:

  • Increased plasma concentration when co-administered with substrates of P-gp or BCRP
  • Decreased serum concentration with strong CYP3A4 inducers
  • Increased serum concentration with strong CYP3A4 inhibitors

Inform your physician about the drugs you take including over-the-counter medications, prescribed drugs, supplements and vitamins. 

This is not a complete list of drug interactions. Approach your physician or pharmacist for more details. 

The effects of certain medications can change if you consume different medications or herbal products simultaneously. This can build your risk for side effects or may cause your drugs not to work effectively. These interactions are conceivable, yet don’t generally happen. Your physician or pharmacist can prevent or oversee interactions by changing how you utilize your prescriptions or by close checking. 

While utilizing this drug, don’t start, stop, or change the dose of other medicines you are using without your physician’s advice. 

If an overdose is suspected, call your healthcare provider immediately.

Available Brands:

  • Ponatinib

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