ICLUSIG

Iclusig is a prescription medication used to treat the symptoms of Acute Lymphoblastic Leukemia and Chronic Myeloid Leukemia. It may be used alone or in combination with other drugs.

Additionally, Iclusig belongs to the Antineoplastics, Tyrosine Kinase Inhibitor class of medicines, which inhibits the development of specific cancer cells. Iclusig is frequently used after other comparable drugs have failed.

Use this medication precisely as recommended by your physician. Follow the prescription of your doctor carefully.

The medication dose your physician has given is based on your condition, other medications or food supplements you may take, and your reaction to treatment. To diminish your risks for adverse effects, don’t increase your dosage. Take it regularly, or take it as instructed by your physician. Adverse events may still happen even at usual prescription dosages.

If your physician requests you to use this drug consistently, use it regularly to get the most benefits from it. To make you remember it better, take it at a fixed time every day.

Your doctor may need to modify your dosages to ease your symptoms or if you develop adverse reactions.

If you have any inquiries with regards to information, ask your physician or pharmacist.

Uses

Iclusig is used in the following conditions:

Intolerance to nilotinib or dasatinib
Philadelphia chromosome positive acute lymphoblastic leukemia
Adults with chronic, accelerated, or blast phase of chronic myeloid leukemia resistant to dasatinib or nilotinib
T315I mutation
Chronic myeloid leukemia

This medicine may be recommended for different uses. Approach your physician or pharmacist for more information.

Warnings

Do not use Iclusig in people with the following conditions:

Hypersensitivity

Side Effects

May have the following side effects:

Anemia
Decreased appetite
Headache
HTN
Cough
Diarrhea
Constipation
Increased lipase
Rash
Pruritus
Arthralgia
Extreme pain
Muscle spasms
Asthenia
Pyrexia
Upper respiratory tract infection
Decreased neutrophil/platelet count
Insomnia
Dizziness
Dyspnea
Abdominal pain
Vomiting
Nausea
Increased AST/ALT
Dry skin
Bone pain
Myalgia
Back pain
Fatigue
Peripheral edema

Keep in mind that your physician has recommended this drug since he or she has known that the advantage to you is more noteworthy than the risk of adverse reactions. Many individuals utilizing this medicine don’t have serious side effects.

A serious allergy to this medication is uncommon. In any case, seek emergency medical help if you see any manifestations of a serious allergic response, including a rash, tingling or swelling particularly of the face or tongue or throat, dizziness or difficulty in breathing.

This is not a complete list of side effects. If you see other effects not recorded above, contact your physician or pharmacist.

Precautions

Take extra caution in patients with the following medical conditions:

Fatal MI
Retinal arteries occlusions that have been associated with persistent vision loss or impairment
Severe peripheral vascular disease
Aneurysm
Pancreatitis
Hemorrhage
Posterior reversible encephalopathy syndrome
QT prolongation
Glucose-galactose malabsorption
Pregnancy
Children
Myelosuppression
Stroke
Stenosis of large arterial vessels of the brain
Renal artery stenosis
Artery dissections
Haptoxicity
Hepatitis B reactivation
Risk of bleeding with anti-clotting agents
Galactose intolerance
Hepatic or renal impairment
Lactation

Prior to taking this medicine, tell your physician or pharmacist if you are allergic to it, or if you have some other hypersensitivities. This drug may contain inert ingredients which can cause unfavorable side effects or different issues. Talk with your pharmacist for more information.

Interactions

Iclusig may interact with the following medicines:

Increased plasma concentration when co-administered with substrates of P-gp or BCRP
Decreased serum concentration with strong CYP3A4 inducers
Increased serum concentration with strong CYP3A4 inhibitors

Inform your physician about the drugs you take including over-the-counter medications, prescribed drugs, supplements and vitamins.

This is not a complete list of drug interactions. Approach your physician or pharmacist for more details.

The effects of certain medications can change if you consume different medications or herbal products simultaneously. This can build your risk for side effects or may cause your drugs not to work effectively. These interactions are conceivable, yet don’t generally happen. Your physician or pharmacist can prevent or oversee interactions by changing how you utilize your prescriptions or by close checking.

While utilizing this drug, don’t start, stop, or change the dose of other medicines you are using without your physician’s advice.

Overdose & Brands

If an overdose is suspected, call your healthcare provider immediately.

Available Brands:

Ponatinib