HYDROFLUMETHIAZIDE

Hydroflumethiazide is a drug that reduces the reabsorption of electrolytes from the renal tubules of the kidneys. It enhances the excretion of sodium and chloride ions and water. It additionally reduces the glomerular filtration rate in the kidneys.

Uses

Hydroflumethiazide is used in the treatment of edema and hypertension.

Warnings

Hydroflumethiazide should not be used in people with the following medical conditions:

Severe liver or kidney impairment
Anuria
Addison’s disease
Hypercalcemia
Pregnancy
Lactation

Side Effects

Hydroflumethiazide may give rise to the following side effects:

Electrolyte imbalance
Hyperglycemia
Gout
Dry mouth
Thirst
Weakness
Muscle pain and cramps
Seizures
Hypotension
Gastrointestinal disturbances
Anorexia
Sialadenitis
Headache
Impotence
Hypersensitivity reactions
Cholestatic jaundice
Pancreatitis
Blood dyscrasias
Glycosuria
Dizziness
Photosensitivity reactions
Postural hypotension
Paraesthesia

Precautions

Precautions

Special precautions should be observed in people with the following conditions:

Fluid and electrolyte disturbances
Liver cirrhosis
Gout
Diabetes mellitus
Elderly
Severe heart failure
Kidney or liver impairment
Monitor blood glucose concentrations in patients taking antidiabetics

Interactions

Hydroflumethiazide may interact with the following medicines:

Digitalis glycosides
Drugs that prolong QT interval
Other antihypertensives
Competitive muscle relaxants
Pressor amines
Corticosteroids
Corticotrophin
β2-agonists
α-blockers
ACE inhibitors
NSAIDs
Alcohol
Barbiturates
Opioids
Lithium
Allopurinol
Tetracyclines
Carbenoxolone
Hypoglycemics

Overdose & Brands

Symptoms of Hydroflumethiazide overdose include the following:

Lethargy
Nausea
Weakness and electrolyte imbalance
Possibly progress to coma within a few hours with minimal depression of respiratory and heart function and with no evidence of dehydration or serum electrolyte changes
Gastrointestinal irritation and hypermotility
Temporary elevation of blood urea nitrogen (BUN) levels
Serum electrolyte changes (example hypokalemia, hypochloremia, hyponatremia) may occur in kidney disease patients

Seek medical help immediately.

Available Brands:

Aldazide