Hydrocortisone is a glucocorticoid and mineralocorticoid corticosteroid having glucocorticoid and mineralocorticoid action. It decreases inflammation by inhibiting the movement of polymorphonuclear leukocytes and reversing enhanced capillary permeability. Neomycin is a kind of aminoglycoside antibiotic. It suppresses bacterial protein production by attaching to sensitive bacteria’s 30S ribosomal subunits. Polymyxin B is a bactericidal that kills gram-negative bacteria. It binds to phospholipids in cell membranes, increasing permeability and breaking the bacterial cytoplasmic membrane, allowing intracellular contents to seep out, which is necessary for bacterial survival.

Use this medication precisely as recommended by your physician. Follow the prescription of your doctor carefully.

The medication dose given by your physician is based on your health conditions, other medications or food supplements taken, and your reaction to the treatment. To diminish risks for adverse effects, do not increase your dosage, thus take it regularly, or take it as instructed by your physician. Adverse events may still happen even at usual prescription dosages.

If your physician requests you to use this drug consistently, take it regularly to get the most benefits from it. To make you remember it better, take it at a fixed time every day.

Your doctor may need to modify your dosages to ease your symptoms or if you develop adverse reactions.

Hydrocortisone + Neomycin + Polymyxin B is used in the following conditions:

  • Ocular inflammation with an existing bacterial infection
  • Ocular inflammation with risk of bacterial infection
  • Otic infections
  • Otitis externa
  • Corticosteroid-responsive dermatoses with secondary infection

This medicine may be recommended for different uses. Approach your physician or pharmacist for more information.

Do not use Hydrocortisone + Neomycin + Polymyxin B in people with the following conditions:

  • Hypersensitivity
  • Fungal, or viral infections of the external auditory canal, ocular structures, and of the skin
  • Perforated tympanic membrane

Hydrocortisone + Neomycin + Polymyxin B may have the following side effects:

  • Hypothalamic-pituitary-adrenal (HPA) axis suppression
  • Immunosuppression
  • Kaposi sarcoma (prolonged treatment)
  • Neomycin sensitization
  • Cushing’s syndrome
  • Hyperglycemia
  • Glycosuria
  • Ototoxicity
  • Permanent sensorineural hearing loss due to cochlear damage
  • Ocular hypertension and/or glaucoma
  • Damage to the optic nerve
  • Visual acuity and fields of vision defects
  • Corneal and scleral thinning (leading to perforation)
  • Posterior subcapsular cataract formation
  • Delayed healing or increased incidence of bleb formation following cataract surgery
  • Stinging and burning sensation in the ears
  • Eye irritation
  • Hypersensitivity
  • Pruritus
  • Skin irritation
  • Burning sensation
  • Xerosis
  • Hypertrichosis
  • Acneiform eruptions
  • Folliculitis
  • Skin hypopigmentation
  • Allergic contact dermatitis
  • Perioral dermatitis
  • Maceration of the skin
  • Striae
  • Skin atrophy
  • Miliaria

Potentially Fatal:

  • Anaphylaxis

Keep in mind that your physician has recommended this drug since he or she has known that the advantage to you is more significant than the risk of adverse reactions. Many individuals utilizing this medicine don’t have serious side effects.  

A severe allergy to this medication is uncommon. In any case, seek emergency medical help if you see any manifestations of a serious allergic response, including a rash, tingling or swelling particularly of the face or tongue or throat, dizziness or difficulty in breathing.

This is not a complete list of side effects. If you see other effects not recorded above, contact your physician or pharmacist.

Take extra caution in patients with the following medical conditions:

  • Glaucoma
  • History of ocular herpes simplex
  • Renal impairment
  • Children
  • Elderly
  • Pregnancy
  • Lactation

Prior to taking this medicine, tell your physician or pharmacist if you have allergies or other hypersensitivity reactions with the drug. This drug may contain inert ingredients which can cause unfavorable side effects or different issues. Talk with your pharmacist for more information.


Hydrocortisone + Neomycin + Polymyxin B may interact with the following medicines:

Neomycin and polymyxin B:

  • Tubocurarine
  • Succinylcholine

Inform your physician about the drugs you take including over-the-counter medications, prescribed drugs, supplements, and vitamins.

This is not a complete list of drug interactions. Approach your physician or pharmacist for more details.

The effects of certain medications can change if you consume different medications or herbal products simultaneously. This can build your risk for side effects or may cause your drugs not to work effectively. These interactions are possible, yet don’t generally happen. Your physician or pharmacist can prevent or oversee interactions by changing how you utilize your prescriptions or by close checking.

While utilizing this drug, don’t start, stop, or change the dose of other medicines you are using without your physician’s advice.

If an overdose is suspected, call your health care provider immediately.

Available brands:

  • Isonep H
  • Hydrospor
  • Ircos

Related Articles


Kapirox-20 belongs to a class of medications known as nonsteroidal anti-inflammatory drugs (NSAIDs). It works by lowering hormones in the [...]


Juvenaid is a nutritious drink used to help exhausted individuals after surgery or who need to gain lean body mass. [...]


Juvelon E+ tablets include sodium fluoride and eleven vital vitamins in a chewable tablet form. Because the pills are chewable, [...]