GLIPIZIDE-METFORMIN

Glipizide/metformin is a sulfonylurea and biguanide antidiabetic combination. Both medicines used to help lower the blood sugar levels. The sulfonylurea works by causing the pancreas to release insulin. The biguanide decreases the amount of sugar that the liver produces and the intestines absorb, and it also helps to make your body more sensitive to the insulin that you naturally produce.

This anti-diabetic medication is a combination of 2 drugs—glipizide and metformin which control high blood sugar in patients with type 2 diabetes. It is used along with a diet and exercise program.

If you are 80 years old or older, do not begin to take glipizide/metformin unless lab tests show that you do not have decreased kidney function. It should not be taken also by people who have severe infection, have low blood oxygen levels, or are dehydrated. Inform your doctor you take glipizide/metformin before you have any surgery or lab procedures.

Symptoms that may occur are: nausea, diarrhea, stomach upset, muscle aches, or headache may occur. Tell your doctor or pharmacist promptly if any of these effects persist or worsen. Stomach symptoms that occur after the first days of your treatment may be a sign of lactic acidosis. If stomach symptoms return later (after you are on the same dose for several days or weeks), tell your doctor right away.

Precautions

Some medical conditions may interact with glipizide/metformin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have had a severe allergic reaction (eg, a severe rash, hives, breathing difficulties, dizziness) to any other sulfonamide medicine, such as acetazolamide, celecoxib, certain diuretics (eg, hydrochlorothiazide), probenecid, sulfamethoxazole, valdecoxib, or zonisamide
  • you have heart failure, especially heart failure that is treated by medicine
  • if you have a history of heart problems (eg, a heart attack, heart failure), lung or breathing problems, thyroid problems, stomach or bowel problems (eg, a blockage, paralysis), adrenal or pituitary problems, or lactic acidosis
  • if you have vomiting, diarrhea, poor health or nutrition, low blood calcium or vitamin B12 levels, or anemia
  • if you have an infection, fever, recent injury, or moderate to severe burns
  • if you drink alcohol or have a history of alcohol abuse
  • if you or a family member have a condition called glucose-6-phosphate dehydrogenase (G6PD) deficiency
  • if you will be having surgery or certain lab procedures
  • if you take a beta-blocker (eg, propranolol)

 

Interactions

This drug may interact with your other medication. It may change how your medications works either helps you or increase your risk for serious side effects. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.

If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call emergency hotline. Overdose can cause lactic acidosis and low blood sugar. Symptoms of overdose may include: rapid breathing, severe drowsiness, slow/irregular heartbeat.

 

Available brand:

  • Dibizide-M

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