This medication is an inhaler used two times every day for long term control of asthma symptoms. Fluticasone belongs to a class of drugs known as corticosteroids. It works by reducing the irritation and swelling of the airways. Salmeterol belongs to the class of drugs known as long-acting beta agonists. It works by opening airways in the lungs to make breathing easier. Together, they prevent irritation and swelling in the airways, and causes muscles in the airways to relax, opening them for easier breathing.