Fluocinolone + Hydroquinone + Tretinoin is a drug that is made up of Fluocinolone, Hydroquinone and Tretinoin. It is usually applied to the skin. Fluocinolone acetonide is a corticosteroid that is used to treat skin inflammation. Hydroquinone is to treat skin discolorations. Tretinoin is a retinoid that increases cell regrowth and turnover.