Currently, fish poisoning ciguatera can only be diagnosed according to the present symptoms, reef fish consumption, and excluding other illnesses that cause the symptoms.
CFP has symptoms similar to Paralytic and Neurotoxic Shellfish Poisonings, scombroid and pufferfish toxicity, botulism, enterovirus, bacteremia, eosinophilic meningitis, and multiple sclerosis, among other conditions.
The definitive diagnosis of CFP would include the affirmation of toxins in the consumed fish through proper laboratory methods. This being accompanied by screening multiple individuals who consumed the same fish, and checking if individuals experience signs, symptoms, time consistent with fish poisoning ciguatera.
There have been attempts to create various treatments that aim to counter symptoms of fish poisoning ciguatera. However, there has been a scarce amount of reliable, random, and controlled tests to discover the level of effectiveness of the treatments.
Mannitol, on the other hand, was previously used after one study claimed a reversal of symptoms. Succeeding studies in animals and reports on people also revealed benefits from mannitol. However, other studies concluded that mannitol does not show treatment; one patient showed total recovery 24 hours without taking any form of cure.