FIDAXOMICIN

Fidaxomicin is a drug that belongs to a class of medicines known as macrocyclic antibiotics. It inhibits the bacterium Clostridium difficile through inhibition of RNA synthesis within its cells by binding to RNA polymerase sigma subunit. It is usually given by the mouth.

Uses

Fidaxomicin is used in the treatment of diarrhoea and colitis caused by the bacterium Clostridium difficile.

Warnings

Do not give to people with known hypersensitivity to Fidaxomicin.

Side Effects

Fidaxomicin can give rise to the following side effects:

Hypersensitivity reactions (e.g. dyspnoea, pruritus, rash, angioedema of mouth, face and throat)
Dizziness
Headache
Nausea
Gastrointestinal haemorrhage
Abdominal pain
Vomiting
Abdominal distention
Tenderness
Dyspepsia
Dysphagia
Flatulence
Intestinal obstruction
Megacolon
Anorexia
Dysgeusia
Constipation
Increased ALT
Anaemia
Neutropenia

Precautions

Extra caution should be given in people with the following medical conditions:

Severe C. difficile infection
Inflammatory bowel disease (e.g. ulcerative colitis or Crohn’s disease, toxic megacolon)
Known macrolide allergy
Systemic infections
Moderate to severe liver impairment
Severe renal impairment
Pregnancy and lactation

Precautions

Precautions

Extra caution should be given in people with the following medical conditions:

Severe C. difficile infection
Inflammatory bowel disease (e.g. ulcerative colitis or Crohn’s disease, toxic megacolon)
Known macrolide allergy
Systemic infections
Moderate to severe liver impairment
Severe renal impairment
Pregnancy and lactation

Interactions

Fidaxomicin may interact with the following medicines:

Sodium picosulfate
Lactobacillus
Estriol
Mizolastine
P-gp inhibitor (e.g. ciclosporin)

Overdose & Brands

If you have used Fidaxomicin more than the actual recommended dose, seek medical help immediately.

Available Brands:

Dificid
Dificlir